Evidence map›Paper›PMID 33737655›Full record

ArticleScientific reports2021

The influence of antibiotics on transitory resistome during gut colonization with CTX-M-15 and OXA-162 producing Klebsiella pneumoniae ST15.

Balázs Stercz, Ferenc B Farkas, Ákos Tóth, Márió Gajdács, Judit Domokos, Viola Horváth, Eszter Ostorházi, Nóra Makra, Béla Kocsis, János Juhász and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Comprehensive Genomic Analysis ofMicroorganisms · 2025
    Article
  4. The Roles of a Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024
    Article
  5. Article
  6. A newFrontiers in microbiology · 2024
    Article
  7. Article
  8. Article
  9. Changes in Fecal Carriage of Extended-SpectrumFrontiers in microbiology · 2022
    Article
  10. Review
  11. Colonization Dynamics of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Balázs Stercz *Institute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
Ferenc B Farkas *Institute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
Ákos TóthDepartment of Bacteriology, Mycology and Parasitology, National Public Health Centre, Albert Flórián út 2-6., 1097, Budapest, Hungary.
Márió GajdácsInstitute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
Judit DomokosInstitute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
Viola HorváthDepartment of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4., 1111, Budapest, Hungary.
Eszter OstorháziInstitute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
Nóra MakraInstitute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
Béla KocsisInstitute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.
János JuhászFaculty of Information Technology and Bionics, Péter Pázmány Catholic University, Práter utca 50/A., 1083, Budapest, Hungary.
Balázs LigetiFaculty of Information Technology and Bionics, Péter Pázmány Catholic University, Práter utca 50/A., 1083, Budapest, Hungary.
Sándor PongorFaculty of Information Technology and Bionics, Péter Pázmány Catholic University, Práter utca 50/A., 1083, Budapest, Hungary.
Dóra SzabóInstitute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary. szabo.dora@med.semmelweis-univ.hu.
Semmelweis University · HUPázmány Péter Catholic University · HUBudapest University of Technology and Economics · HUNational Public Health and Medical Officer Service · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Great efforts have been made to limit the transmission of carbapenemase-producing Enterobacteriaceae (CPE), however, the intestinal reservoir of these strains and its modulation by various antibiotics remain largely unexplored. Our aim was to assess the effects of antibiotic administration (ampicillin, ceftazidime, ciprofloxacin) on the establishment and elimination of intestinal colonization with a CTX-M-15 ESBL and OXA-162 carbapenemase producing Klebsiella pneumoniae ST15 (KP5825) in a murine (C57BL/6 male mice) model. Whole genome sequencing of KP5825 strain was performed on an Illumina MiSeq platform. Conjugation assays were carried out by broth mating method. In colonization experiments, 5 × 10

Indexed as

AnimalsAnti-Bacterial Agentsbeta-LactamasesDrug Resistance, BacterialGenome, BacterialHumansKlebsiella InfectionsKlebsiella pneumoniaeMiceMicrobial Sensitivity TestsPlasmidsWhole Genome SequencingAnti-Bacterial Agentsbeta-Lactamasesoxacillinase

Identifiers

PMID33737655
PMCPMC7973416
OpenAlexW3137358008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.