ArticleScientific reports2021
Destruction of Staphylococcus aureus biofilms by combining an antibiotic with subtilisin A or calcium gluconate.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Biochemical and Structural Characterization of Two-domain Glycoside Hydrolase PgaB fromACS infectious diseases · 2026Article
- Alternative and Synergistic Strategies Against Antibiotic-ResistantInternational journal of microbiology · 2026Review
- Biofilm-associated genes inFrontiers in microbiology · 2026Review
- Article
- Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis.bioRxiv : the preprint server for biology · 2025Article
- The Impact of Antibiofilm Strategies in Controlling Microbial Colonization.Current microbiology · 2025Review
- Population and pan-genomic analyses ofApplied and environmental microbiology · 2025Article
- Antibiofilm activity of Plumbagin against Staphylococcus aureus.Scientific reports · 2025Article
- Attachment of Proteolytic Enzyme Inhibitors to Vascular Prosthesis-An Analysis of Binding and Antimicrobial Properties.Molecules (Basel, Switzerland) · 2024Article
- In Vitro Activities of Oxazolidinone Antibiotics Alone and in Combination with C-TEMPO against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Effect of poly (lactic-co-glycolic acid) polymer nanoparticles loaded with vancomycin against Staphylococcus aureus biofilm.BMC biotechnology · 2023Article
- Drug delivery strategies for antibiofilm therapy.Nature reviews. Microbiology · 2023Review
- Inhibition of bacterial adhesion and anti-biofilm effects ofIranian journal of microbiology · 2023Article
- Biology and Regulation of Staphylococcal Biofilm.International journal of molecular sciences · 2023Review
- Hydrolytic Enzymes as Potentiators of Antimicrobials against an Inter-Kingdom Biofilm Model.Microbiology spectrum · 2022Article
- Production of Gluconic Acid and Its Derivatives by Microbial Fermentation: Process Improvement Based on Integrated Routes.Frontiers in bioengineering and biotechnology · 2022Review
- Enhancement of Antibiofilm Activity of Ciprofloxacin againstAntibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In S. aureus biofilms, bacteria are embedded in a matrix of extracellular polymeric substances (EPS) and are highly tolerant to antimicrobial drugs. We thus sought to identify non-antibiotic substances with broad-spectrum activity able to destroy the EPS matrix and enhance the effect of antibiotics on embedded biofilm bacteria. Among eight substances tested, subtilisin A (0.01 U/mL) and calcium gluconate (CaG, Ca
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Registered trials
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