ArticleScientific reports2021
Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Assessing health in aging male and female mice: does cardiac function dictate frailty or physical resilience?The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Associations of common infections with frailty and mortality in two UK cohort studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The Impact of Frailty on Left Ventricle Mass and Geometry in Elderly Patients with Normal Ejection Fraction: A STROBE-Compliant Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Association between frailty and echocardiographic findings in hospitalized older adults with preserved ejection fraction.European heart journal open · 2025Article
- Accelerated DNA methylation age plays a role in the impact of cardiovascular risk factors on the human heart.Clinical epigenetics · 2023Article
- Bidirectional Association Between Frailty and Cardiac Structure and Function: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2023Article
- Correlation between frailty and cardiac structure and function in echocardiography in elderly patients with normal ejection fraction.Aging clinical and experimental research · 2023Article
- Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development.BMC cardiovascular disorders · 2022Article
- Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation-Results From the 1946 British Birth Cohort.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A frailty index (FI) counts health deficit accumulation. Besides traditional risk factors, it is unknown whether the health deficit burden is related to the appearance of cardiovascular disease. In order to answer this question, the same multidimensional FI looking at 45-health deficits was serially calculated per participant at 4 time periods (0-16, 19-44, 45-54 and 60-64 years) using data from the 1946 Medical Research Council (MRC) British National Survey of Health and Development (NSHD)-the world's longest running longitudinal birth cohort with continuous follow-up. From these the mean and total FI for the life-course, and the step change in deficit accumulation from one time period to another was derived. Echocardiographic data at 60-64 years provided: ejection fraction (EF), left ventricular mass indexed to body surface area (LVmassi, BSA), myocardial contraction fraction indexed to BSA (MCF
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.