Evidence map›Paper›PMID 33737527›Full record

SynthesisScientific reports2021

Epidemiology and outcomes of COVID-19 in HIV-infected individuals: a systematic review and meta-analysis.

Paddy Ssentongo, Emily S Heilbrunn, Anna E Ssentongo, Shailesh Advani, Vernon M Chinchilli, Jonathan J Nunez, Ping Du

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 17 pooled it
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 17 syntheses or guidelines pooled it, 330 citations in OpenAlex.

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  10. Immunogenicity and efficacy of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Paddy SsentongoDepartment of Public Health Sciences, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA. pssentongo@pennstatehealth.psu.edu.
Emily S HeilbrunnDepartment of Public Health Sciences, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA.ORCID 0000-0002-9868-5495
Anna E SsentongoDepartment of Public Health Sciences, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA.
Shailesh AdvaniDepartment of Oncology, Georgetown University School of Medicine, Georgetown University, Washington, DC, USA.
Vernon M ChinchilliDepartment of Public Health Sciences, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA.
Jonathan J NunezDepartment of Medicine, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA.
Ping DuDepartment of Public Health Sciences, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · USGeorgetown University · USPennsylvania State University · US

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R01AI14505
6 · The paper itself

Abstract

Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk of mortality among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLWHA) is largely unknown. PLWHA are unique due to their altered immune system from their history of chronic HIV infection and their use of antiretroviral therapy, some of which have been used experimentally to treat coronavirus disease 2019 (COVID-19). Therefore, we conducted a systematic review and meta-analysis to assess the epidemiology of SARS-COV-2/HIV coinfection and estimate associated mortality from COVID-19 (Prospero Registration ID: CRD42020187980). PubMed, SCOPUS, OVID and Cochrane Library databases, and medRxiv preprint repositories were searched from January 1, 2020, to December 12, 2020. Data were extracted from studies reporting COVID-19 attack and mortality rates in PLWHA compared to their HIV-negative counterparts. Pooled attack and mortality risks were quantified using random-effects models. We identified 22 studies that included 20,982,498 participants across North America, Africa, Europe, and Asia. The median age was 56 years, and 50% were male. HIV-positive persons had a significantly higher risk of SARS-CoV-2 infection [risk ratio (RR) 1.24, 95% CI 1.05-1.46)] and mortality from COVID-19 (RR 1.78, 95% CI 1.21-2.60) than HIV-negative individuals. The beneficial effects of tenofovir and protease-inhibitors in reducing the risk of SARS-CoV-2 infection and death from COVID-19 in PLWHA remain inconclusive. HIV remains a significant risk factor for acquiring SARS-CoV-2 infection and is associated with a higher risk of mortality from COVID-19. In support of the current Centers for Disease Control and Prevention (CDC) guidelines, persons with HIV need priority consideration for the SARS-CoV-2 vaccine.

Indexed as

COVID-19Disease SusceptibilityHIV InfectionsHumansSARS-CoV-2

Identifiers

PMID33737527
PMCPMC7973415
OpenAlexW3136863660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.