ArticleNPJ schizophrenia2021
Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity.
Article in NPJ schizophrenia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Cognitive pleiotropy reveals disorder-specific and shared biology for schizophrenia and bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Associations among homocysteine, left cortical thickness, and working memory in patients with treatment-resistant schizophrenia: preliminary findings of a cohort study.BMC psychiatry · 2026Article
- Widespread cortical thinning and subcortical alterations in mood and psychotic disorders across first-episode and chronic stages.Journal of affective disorders · 2026Article
- The awareness, characterization, and burden of Cognitive Impairment Associated with Schizophrenia (CIAS) in clinical practice: Results from a nationwide survey in Italy.Schizophrenia research. Cognition · 2025Article
- Systematic review and meta-analysis of early visual processing, social cognition, and functional outcomes in schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2025Review
- Article
- Cognitive symptoms in schizophrenia: an analysis of awareness, assessment, and management practices among psychiatrists and primary care physicians.Frontiers in psychiatry · 2025Article
- A multimodal ensemble stacking model improves brain age prediction and reveals associations with schizophrenia symptoms.Frontiers in psychiatry · 2025Article
- Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review.Schizophrenia research · 2024Review
- Sulcal variability in anterior lateral prefrontal cortex contributes to variability in reasoning performance among young adults.Brain structure & function · 2024Article
- IL-10 (-1082 G/A) polymorphism in Bataknese with schizophrenia.Journal of Taibah University Medical Sciences · 2024Article
- Cortical thickness and grey-matter volume anomaly detection in individual MRI scans: Comparison of two methods.NeuroImage. Clinical · 2024Article
- Article
- Constructing the Schizophrenia Recognition Method Employing GLCM Features from Multiple Brain Regions and Machine Learning Techniques.Diagnostics (Basel, Switzerland) · 2023Article
- Cognitive impairment in adults under compulsory psychiatric care: association with psychotic symptoms and high-dose antipsychotics.BJPsych open · 2023Article
- Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study.Human brain mapping · 2023Article
- Associations with youth psychotic-like experiences over time: Evidence for trans-symptom and specific cognitive and neural risk factors.Journal of psychopathology and clinical science · 2023Article
- Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.Schizophrenia research · 2023Article
- Resting-State EEG Connectivity at High-Frequency Bands and Attentional Performance Dysfunction in Stabilized Schizophrenia Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Cortical thinning in chemotherapy-treated older long-term breast cancer survivors.Brain imaging and behavior · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cognitive impairments are a core and persistent characteristic of schizophrenia with implications for daily functioning. These show only limited response to antipsychotic treatment and their neural basis is not well characterised. Previous studies point to relationships between cortical thickness and cognitive performance in fronto-temporal brain regions in schizophrenia patients (SZH). There is also evidence that these relationships might be independent of symptom severity, suggesting dissociable disease processes. We set out to explore these possibilities in a sample of 70 SZH and 72 age and gender-matched healthy controls (provided by the Center of Biomedical Research Excellence (COBRE)). Cortical thickness within fronto-temporal regions implicated by previous work was considered in relation to performance across various cognitive domains (from the MATRICS Cognitive Battery). Compared to controls, SZH had thinner cortices across most fronto-temporal regions and significantly lower performance on all cognitive domains. Robust relationships with cortical thickness were found: visual learning and attention performance correlated with bilateral superior and middle frontal thickness in SZH only. Correlations between attention performance and right transverse temporal thickness were also specific to SZH. Findings point to the importance of these regions for cognitive performance in SZH, possibly reflecting compensatory processes and/or aberrant connectivity. No links to symptom severity were observed in these regions, suggesting these relationships are dissociable from underlying psychotic symptomology. Findings enhance understanding of the brain structural underpinnings and possible aetiology of cognitive impairment in SZH.
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Registered trials
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