Evidence map›Paper›PMID 33737501›Full record

ArticleJournal of biosciences2021

Advances in Bone tissue engineering: A fundamental review.

Bruna Maria Manzini, Leonardo Mendes Ribeiro Machado, Pedro Yoshito Noritomi, Jorge Vicente Lopes DA Silva

Abstract read
PubMed
In one paragraph

Article in Journal of biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 121 citations in OpenAlex.

  1. Review
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  5. International journal of molecular sciences · 2026
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  12. A Bio-Inspired Perspective on Materials Sustainability.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bruna Maria ManziniNucleus of Three-Dimensional Technologies, Renato Archer Information Technology Center - CTI, Campinas CEP 13069-901, Brazil.
Leonardo Mendes Ribeiro Machado
Pedro Yoshito Noritomi
Jorge Vicente Lopes DA Silva
Centro de Tecnologia da Informação Renato Archer · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone is a dynamic tissue that can always rebuild itself by modeling and remodeling to maintain functionality. This tissue is responsible for several vital functions in the body, such as providing structural support for soft tissues and the body, being the central region of hematopoiesis in human adults, and contributing to mineral homeostasis. Besides, it has an innate ability of auto-regeneration when damaged. All of these processes involve several molecular cues related to biochemical and mechanical stimulus. However, when the lesion is complicated or too big, it is necessary to intervene surgically, which may not effectively solve the problem. Bone tissue engineering seeks to provide resources to resolve these clinical issues and has been advancing in recent years, presenting promising devices for bone tissue repair. The understanding of some important biofactors and bone stem-cells influence might be crucial for an effective regenerative medicine, since bone is one of the most transplanted tissues. So, the purpose of this article is to provide an overview of the bone tissue, including the role of stem cells and some of the bioactive molecules associated with these processes. Finally, we will suggest future directions for bone tissue engineering area that might be helpful in order to produce biomimetic bone substitutes that become a real alternative to translational medicine.

Indexed as

Biocompatible MaterialsAnimalsBone and BonesBone RemodelingFractures, BoneHumansStem CellsTissue EngineeringBiocompatible Materials

Identifiers

PMID33737501
OpenAlexW3138933334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.