Evidence map›Paper›PMID 33737494›Full record

ArticleJournal of biosciences2021

Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer.

Weiquan Xie, L U Liu, Chuanyong He, Min Zhao, Rong Ni, Zixiong Zhang, Chengyu Shui

Abstract read
PubMed
In one paragraph

Article in Journal of biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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  5. Role of circular RNA as competing endogenous RNA in ovarian cancer (Review).International journal of molecular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Weiquan XieDepartment of Obstetrics and Gynaecology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi City, Hubei Province, China.
L U Liu
Chuanyong He
Min Zhao
Rong Ni
Zixiong Zhang
Chengyu Shui
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been well investigated that circular RNAs (circRNAs) play important roles in various cancers. The function of circ_0002711 and its underlying mechanisms in ovarian cancer (OC) remain unknown. qRT-PCR and western blot were performed to detect the expressions of circ_0002711, microRNA-1244 (miR-1244), and Rho kinase 1 (ROCK1) in OC tissues and cells. MTT assay and colony formation assay were employed to evaluate cell proliferation. Detection of lactate production, glucose uptake, and ATP level and oxygen consumption were used to determine Warburg effect. Western blot was used to examine glycolysis or proliferationrelated genes. Dual-luciferase reporter assay and RIP pull down assay were used to address the relationship among circ_0002711, miR-1244, and ROCK1.

Indexed as

AerobiosisAnimalsCell ProliferationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGlycolysisHumansMiceMice, NudeMicroRNAsOvarian Neoplasmsrho-Associated KinasesRNA, CircularXenograft Model Antitumor AssaysMicroRNAsMIRN1244 microRNA, humanrho-Associated KinasesRNA, CircularROCK1 protein, human

Identifiers

PMID33737494
OpenAlexW3138773091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.