ArticleGenes & development2021
Mutant p53 regulates Survivin to foster lung metastasis.
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Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy.Cancer cell · 2025Review
- Article
- CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status.Cancer gene therapy · 2024Article
- Multifaceted roles of CCAR family proteins in the DNA damage response and cancer.Experimental & molecular medicine · 2024Review
- p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.Cancer discovery · 2023Article
- Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets.The Journal of clinical investigation · 2023Article
- Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway.Journal of cancer research and clinical oncology · 2023Article
- Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion.Gastroenterology · 2023Article
- Vaccination and Microbiota Manipulation Approaches for Colon Cancer Prevention in Rodent Models.Cancer prevention research (Philadelphia, Pa.) · 2023Review
- Diclofenac exhibits cytotoxic activity associated with metabolic alterations and p53 induction in ESCC cell lines and decreases ESCC tumor burden in vivo.Carcinogenesis · 2023Article
- Specific regulation of BACH1 by the hotspot mutant p53Nature cancer · 2023Article
- Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis.Acta biochimica et biophysica Sinica · 2023Article
- The role of p53 in anti-tumor immunity and response to immunotherapy.Frontiers in molecular biosciences · 2023Review
- Pan-cancer analysis identifies BIRC5 as a prognostic biomarker.BMC cancer · 2022Article
- A BIRC5Cancer informatics · 2022Article
- Development of Multi-Scale X-ray Fluorescence Tomography for Examination of Nanocomposite-Treated Biological Samples.Cancers · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 2 countries.
Qiaosi TangAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Gizem EfeHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Anna M ChiarellaHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Jessica LeungProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0001-9682-9160
Maoting ChenHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Taiji YamazoeAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Zhenyi SuHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Jason R PitarresiAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Jinyang LiAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Mirazul IslamDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA.
Tatiana KarakashevaAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Andres J Klein-SzantoDepartment of Pathology, Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19104, USA.
Samuel PanHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Jianhua HuHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Shoji NatsugoeDepartment of Digestive Surgery, Kagoshima University, Sakuragaoka, Kagoshima 890-0065, Japan.
Wei GuHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Ben Z StangerAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0003-0410-4037
Kwok-K WongNew York University Langone Center, New York, New York 10016, USA.
J Alan DiehlCase Western University, Cleveland, Ohio 44106, USA.
Adam J BassDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Hiroshi NakagawaHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Maureen E MurphyProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Anil K RustgiHerbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.
Columbia University Irving Medical Center · USUniversity of Pennsylvania · USThe Wistar Institute · USCase Western Reserve University · USDana-Farber Cancer Institute · USFox Chase Cancer Center · USKagoshima University · JPNYU Langone Health · USVanderbilt University · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9MTransformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HIBSHOOSH, HANINA · 2003 to 2023
$31.7MTRAINING PROGRAM IN BASIC CANCER RESEARCHT32CA009171 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$15.3MFunctional Analysis of p53 Polymorphic Variants - Diversity SupplementR01CA102184 · NCI · WISTAR INSTITUTE · PI Maureen E. Murphy · 2005 to 2026
$7.4MPREDOCTORAL TRAINING GRANT IN HUMAN GENETICS &DEVELOPMET32GM007088 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEN, MICHAEL M. · 1985 to 2020
$7.1MThe impact of coding region variants on mutant p53 biologyR01CA238611 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2020 to 2024
$2.2Mp53 Variants in Cancer Risk and TherapyR01CA201430 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2016 to 2020
$2.2MDissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancerK99CA252153 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PITARRESI, JASON R. · 2021 to 2022
$275kThe role of p120ctn in PDAC epithelial-to-mesenchymal transition and metastasisF32CA221094 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PITARRESI, JASON R. · 2017 to 2018
$115kNCI NIH HHS F32 CA221094NCI NIH HHS K99 CA252153NCI NIH HHS P01 CA098101NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA102184NCI NIH HHS R01 CA201430NCI NIH HHS R01 CA238611NCI NIH HHS T32 CA009171NIGMS NIH HHS T32 GM007088
Abstract
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis.
Indexed as
AnimalsCell Line, TumorDisease Models, AnimalGene Expression Regulation, NeoplasticLung NeoplasmsMiceMutationNeoplasm MetastasisSurvivinTranscriptomeTumor Suppressor Protein p53SurvivinTumor Suppressor Protein p53metastasismutant p53SurvivinYAP
Identifiers
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.