ArticleNeurology2021
Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05147532 (Remyelination in Multiple Sclerosis), which is not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Remyelination in Multiple Sclerosis: a PET-MR Longitudinal Study Investigating Individual Profiles of Myelin Repair and the Contribution of Neuroinflammation
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Evaluating the Clinical Utility of TSPO-PET in MS and the Influence of Methodological Heterogeneity: A Systematic Review and Meta-Analysis.Neurology(R) neuroimmunology & neuroinflammation · 2026Pooled it
- Choroid plexus volume in multiple sclerosis: a systematic review and meta-analysis of an emerging imaging biomarker.European journal of medical research · 2025Pooled it
- Choroid plexus volume changes in multiple sclerosis: insights from a systematic review and meta-analysis of magnetic resonance imaging studies.Neuroradiology · 2024Pooled it
- Cerebrospinal fluid inflammatory biomarkers for disease progression in Alzheimer's disease and multiple sclerosis: a systematic review.Frontiers in immunology · 2023Pooled it
- Baseline Neuroinflammation Stratifies TSPO-PET Response to Disease-Modifying Therapy in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases.Journal of advanced research · 2026Article
- Left Pulvinar Thalamic Tumor with Ventricular Atrial Extension Presenting as Network-Level Cognitive and Gait Dysfunction.Diagnostics (Basel, Switzerland) · 2026Article
- Spinal cord versus brain imaging biomarkers of multiple sclerosis trajectory combining 7T and 3T MRI.Brain communications · 2026Article
- Imaging brain inflammation and blood brain barrier permeability in neurological and psychiatric diseases: a review.Journal of neuroinflammation · 2025Review
- Cell-specific analysis of microglia following partial brain proton irradiation in mice.Clinical and translational radiation oncology · 2025Article
- Relevance of choroid plexus volumes in multiple sclerosis.Fluids and barriers of the CNS · 2025Article
- Identifying Biomarkers for Remyelination and Recovery in Multiple Sclerosis: A Measure of Progress.Biomedicines · 2025Review
- Microstructural Damage and Repair in the Spinal Cord of Patients With Early Multiple Sclerosis and Association With Disability at 5 Years.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRI.Multiple sclerosis and related disorders · 2024Article
- Assessing disease progression and treatment response in progressive multiple sclerosis.Nature reviews. Neurology · 2024Review
- Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes.AJNR. American journal of neuroradiology · 2024Article
- The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells.Molecular neurodegeneration · 2024Review
- PET Study of Microglial Activation in Kleine-Levin Syndrome.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis.Brain : a journal of neurology · 2024Article
- Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
Corrections and comments
- Commented on by
Authors and funding
11 authors at 1 institution in 1 country.
Emilie PoirionFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Matteo ToniettoFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.ORCID 0000-0001-9591-5710
François-Xavier LejeuneFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Vito A G RiciglianoFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Marine Boudot de la MotteFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Charline BenoitFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Géraldine BeraFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Bertrand KuhnastFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Michel BottlaenderFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Benedetta BodiniFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France.
Bruno StankoffFrom the Sorbonne University (E.P., M.T., F.-X.L., V.A.G.R., M.B.d.l.M., C.B., G.B., B.B., B.S.), Paris Brain Institute; Imaging Department (E.P.), Foundation A. de Rothschild Hospital, Paris; Paris-Saclay University (M.T., B.K., M.B.), CEA, Orsay; and Assistance Publique des Hôpitaux de Paris (B.B., B.S.), France. bruno.stankoff@aphp.fr.ORCID 0000-0002-9631-4674
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore in vivo innate immune cell activation as a function of the distance from ventricular CSF in patients with multiple sclerosis (MS) using [
methodsThirty-seven patients with MS and 19 healthy controls underwent MRI and [
resultsThe percentage of DPA+ voxels was higher in patients compared to controls in the periventricular WM (
conclusionsOur results demonstrate that in MS the innate immune cell activation predominates in periventricular regions and is associated with microstructural damage and disability worsening. This could result from the diffusion of proinflammatory CSF-derived factors into surrounding tissues.
Indexed as
AdultCerebral CortexCerebral VentriclesFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedMultiple SclerosisPositron-Emission TomographyWhite Matter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT05147532ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.