Evidence map›Paper›PMID 33737319›Full record

ArticleArchives of disease in childhood2021

Sharing a household with children and risk of COVID-19: a study of over 300 000 adults living in healthcare worker households in Scotland.

Rachael Wood, Emma Thomson, Robert Galbraith, Ciara Gribben, David Caldwell, Jennifer Bishop, Martin Reid, Anoop S V Shah, Kate Templeton, David Goldberg and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Archives of disease in childhood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Variant-Specific Viral Kinetics in Acute COVID-19.The Journal of infectious diseases · 2023
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  17. SARS-CoV-2 infection in households with and without young children: Nationwide cohort study, Denmark, 27 February 2020 to 26 February 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Rachael WoodPublic Health Scotland, Edinburgh, UK.ORCID 0000-0003-4453-623X
Emma ThomsonMRC Centre for Virus Research, University of Glasgow, Glasgow, UK.
Robert GalbraithRetired, Edinburgh, UK.
Ciara GribbenPublic Health Scotland, Edinburgh, UK.
David CaldwellPublic health Scotland, Glasgow, UK.
Jennifer BishopPublic health Scotland, Glasgow, UK.
Martin ReidPublic Health Scotland, Edinburgh, UK.
Anoop S V ShahDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Kate TempletonDepartment of Medical Microbiology, Royal Infirmary of Edinburgh, Edinburgh, UK.
David GoldbergPublic health Scotland, Glasgow, UK.
Chris RobertsonPublic health Scotland, Glasgow, UK.
Sharon J HutchinsonPublic health Scotland, Glasgow, UK.
Helen M ColhounPublic health Scotland, Glasgow, UK.ORCID 0000-0002-8345-3288
Paul M McKeigueUsher Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5217-1034
David A McAllisterPublic health Scotland, Glasgow, UK david.mcallister@glasgow.ac.uk.ORCID 0000-0003-3550-1764
Public Health Scotland · GBEdinburgh Royal Infirmary · GBLondon School of Hygiene & Tropical Medicine · GBMRC University of Glasgow Centre for Virus Research · GBUniversity of Edinburgh · GB

Funding

British Heart Foundation FS/19/17/34172Medical Research Council MC_PC_19026
6 · The paper itself

Abstract

objectiveChildren are relatively protected from COVID-19, due to a range of potential mechanisms. We investigated if contact with children also affords adults a degree of protection from COVID-19.

designCohort study based on linked administrative data.

settingScotland. STUDY POPULATION: All National Health Service Scotland healthcare workers and their household contacts as of March 2020. MAIN EXPOSURE: Number of young children (0-11 years) living in the participant's household. MAIN OUTCOMES: COVID-19 requiring hospitalisation, and any COVID-19 (any positive test for SARS-CoV-2) in adults aged ≥18 years between 1 March and 12 October 2020.

results241 266, 41 198, 23 783 and 3850 adults shared a household with 0, 1, 2 and 3 or more young children, respectively. Over the study period, the risk of COVID-19 requiring hospitalisation was reduced progressively with increasing numbers of household children-fully adjusted HR (aHR) 0.93 per child (95% CI 0.79 to 1.10). The risk of any COVID-19 was similarly reduced, with the association being statistically significant (aHR per child 0.93; 95% CI 0.88 to 0.98). After schools reopened to all children in August 2020, no association was seen between exposure to young children and risk of any COVID-19 (aHR per child 1.03; 95% CI 0.92 to 1.14).

conclusionBetween March and October 2020, living with young children was associated with an attenuated risk of any COVID-19 and COVID-19 requiring hospitalisation among adults living in healthcare worker households. There was no evidence that living with young children increased adults' risk of COVID-19, including during the period after schools reopened.

Indexed as

Family CharacteristicsHealth PersonnelAdultChildChild, PreschoolCohort StudiesCOVID-19COVID-19 TestingCross ProtectionFemaleHospitalizationHumansInfantInfant, NewbornMalePandemicsCOVID-19epidemiology

Identifiers

PMID33737319
PMCPMC7985971
OpenAlexW3136211144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.