Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2021
Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials.
Open access · bronzeAbstract readClinical Trial, Phase IIMulticenter Study
In one paragraph
Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor.Neuro-oncology · 2023Trial
- Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials.Acta neuropathologica · 2022Trial
- High-dose chemotherapy with autologous stem cell rescue in children under 5 years of age with central nervous system embryonal tumors: results from a prospective cohort in an upper-middle-income country.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Paediatric Therapeutic Development Workshop on rhabdoid tumours.British journal of cancer · 2026Review
- Clinicopathological Characterization of Pediatric Atypical Teratoid/Rhabdoid Tumors and an HE-IHC Dual-Path Deep Learning Model for Auxiliary Diagnosis.Diagnostics (Basel, Switzerland) · 2026Article
- Pediatric Spinal Atypical Teratoid Rhabdoid Tumor: Recent Advances in Biology and Management Options.Cancers · 2026Review
- Aggressive atypical teratoid/rhabdoid tumor with extensive leptomeningeal metastasis in an 8-year-old boy: a case report and narrative review.Translational pediatrics · 2026Article
- Outcomes following radiotherapy for atypical teratoid/rhabdoid tumor in combination with surgery and intensive chemotherapy: A report from Children's Oncology Group study ACNS0333.Neuro-oncology pediatrics · 2026Article
- Histogenesis of Atypical Teratoid Rhabdoid Tumors: Anatomical and Embryological Perspectives.Cancers · 2025Article
- Clinical and Molecular Characteristics of 100 Atypical Teratoid Rhabdoid Tumor Patients from Low- and Middle-Income Countries.Cancers · 2025Article
- SMARCB1-related schwannomatosis and other SMARCB1-associated phenotypes: clinical spectrum and molecular pathogenesis.Familial cancer · 2025Review
- Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes.Acta neuropathologica communications · 2025Article
- What Have We Learnt from the Recent Multimodal Managements of Young Patients with ATRT?Cancers · 2025Article
- Clinical characteristics of patients with atypical teratoid/rhabdoid tumors: a monocentric retrospective analysis.Frontiers in pediatrics · 2025Article
- Autologous stem cell transplantation in adults with atypical teratoid rhabdoid tumor: a case report and review.CNS oncology · 2024Review
- Desmoplastic myxoid tumor of the pineal region, SMARCB1 mutant: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Outcomes for children with recurrent/refractory atypical teratoid rhabdoid tumor: A single-institution study with molecular correlation.Pediatric blood & cancer · 2024Article
- Rhabdoid tumor predisposition syndrome: A historical review of treatments and outcomes for associated pediatric malignancies.Pediatric blood & cancer · 2024Review
- Atypical teratoid rhabdoid tumor in a lower middle‑income country: Challenges to cure.Oncology letters · 2024Article
- Recurrent spinal atypical teratoid/rhabdoid tumor with pulmonary metastasis.Cancer reports (Hoboken, N.J.) · 2024Article
Corrections and comments
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Authors and funding
33 authors at 12 institutions in 5 countries.
Santhosh A UpadhyayaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee. santhosh.upadhyaya@stjude.org.ORCID 0000-0001-6101-149X
Giles W RobinsonDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-7441-9486
Arzu Onar-ThomasDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Brent A OrrDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-0997-4728
Pascal JohannDepartment of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Gang WuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Catherine A BillupsDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee.
Ruth G TatevossianDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-1653-3026
Sandeep Kumar DhandaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-1381-7434
Ashok SrinivasanDepartment of Bone Marrow Transplant and Cell Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee.
Alberto BroniscerDepartment of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Ibrahim QaddoumiDepartment of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.
Anna VinitskyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Anne E BendelDepartment of Hematology Oncology, Children's Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-2062-0974
Tim HassallDepartment of Medicine, Royal Children's Hospital Brisbane, Brisbane, Queensland, Australia.ORCID 0000-0002-7883-3710
Sonia PartapDepartment of Neurology, Division of Child Neurology, Stanford University, Palo Alto, California.ORCID 0000-0001-5615-7689
Paul G FisherDepartment of Neurology, Division of Child Neurology, Stanford University, Palo Alto, California.
John R CrawfordDepartment of Neurosciences and Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, California.ORCID 0000-0002-4100-7001
Murali ChintagumpalaDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas.
Eric BouffetDepartment of Pediatrics, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-6832-6539
Sridharan GururanganDepartment of Neurosurgery, Preston A. Wells Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, Florida.
Roya MostafaviDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Robert P SandersCommuniCare Health Centers, San Antonio, Texas.
Paul KlimoDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.
Zoltan PatayDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-1479-9864
Daniel J IndelicatoDepartment of Radiation Oncology, University of Florida Health, Jacksonville, Florida.
Kim E NicholsDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-5581-6555
Frederick A BoopDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.
Thomas E MerchantDepartment of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0002-0412-6255
Marcel KoolDepartment of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
David W EllisonDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0003-1239-7757
Amar GajjarDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-5019-0699
St. Jude Children's Research Hospital · USGerman Cancer Research Center · DEPalo Alto University · USAllen Institute for Brain Science · USChildren's Cancer Center · USChildren's Hospital of Pittsburgh · USChildren's Minnesota · USHospital for Sick Children · CAMultiCare Health System · USRady Children's Hospital-San Diego · USRoyal Children's Hospital · AUUniversity of Florida Health · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MNCI NIH HHS P30 CA021765
Abstract
purposeReport relevance of molecular groups to clinicopathologic features, germline MATERIALS AND
methodsSeventy-four participants with newly diagnosed ATRT were treated in two trials: infants (SJYC07: age < 3 years;
resultsTwenty-four participants (32%) were alive at time of analysis at a median follow-up of 8.4 years (range, 3.1-14.1 years). Methylation profiling classified 64 ATRTs as TYR (
conclusionsAmong infants, those with ATRT-TYR had the best OS. ATRT-SHH was associated with metastases and consequently with inferior outcomes. Children with nonmetastatic ATRT benefit from postoperative CSI and adjuvant chemotherapy.
Indexed as
Biomarkers, TumorAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolDiagnosis, DifferentialDisease ManagementDisease SusceptibilityDNA Copy Number VariationsDNA MethylationFemaleGerm-Line MutationHumansInfantMaleMutationPrognosisBiomarkers, TumorSMARCB1 ProteinSMARCB1 protein, human
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