ArticleContemporary clinical trials2021
The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation.
Abstract readClinical Trial Protocol
In one paragraph
Article in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Peer Navigator Intervention and Opioid-Related Adverse Events for Emergency Department Patients: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal.JAMA network open · 2024Trial
- Incidence of Precipitated Withdrawal During a Multisite Emergency Department-Initiated Buprenorphine Clinical Trial in the Era of Fentanyl.JAMA network open · 2023Trial
- Emergency Department-initiated standard versus high-dose buprenorphine induction (ENVISION): a randomised clinical trial protocol.BMJ open · 2026Article
- An adapted brief negotiation interview for alcohol and cannabis use among assault-injured emerging adults: A randomized pilot trial protocol.Contemporary clinical trials · 2026Article
- Drug Use After Emergency Department-Initiated Injectable Buprenorphine: A Secondary Analysis of the ED-INNOVATION Ancillary Safety and Feasibility Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Investigator- and Site-Level Outcomes of Participation in an ED-Based Clinical Trial.JAMA network open · 2026Article
- Exploring Preferences in Emergency Department Coordination of Opioid Use Disorder Treatment by Race and Ethnicity.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Outpatient initiation of direct-to-inject buprenorphine.Drug and alcohol dependence · 2026Article
- Implementation facilitation improves readiness for emergency department-initiated buprenorphine to treat opioid use disorder.Journal of substance use and addiction treatment · 2025Article
- Racial and Ethnic Factors and Opioid Use Disorder Treatment After an Emergency Department Visit.JAMA network open · 2025Article
- Early emergency department experience with 7-day extended-release injectable buprenorphine for opioid use disorder.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023Article
- URINE TOXICOLOGY PROFILES OF EMERGENCY DEPARTMENT PATIENTS WITH UNTREATED OPIOID USE DISORDER: A MULTI-SITE VIEW.The Journal of emergency medicine · 2023Article
- Research Priorities for Expansion of Opioid Use Disorder Treatment in the Community Pharmacy.Substance abuse · 2023Article
- Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population.Addiction science & clinical practice · 2023Article
- National Institute on Drug Abuse Clinical Trials Network Meeting Report: Advancing Emergency Department Initiation of Buprenorphine for Opioid Use Disorder.Annals of emergency medicine · 2023Article
- Implementing Programs to Initiate Buprenorphine for Opioid Use Disorder Treatment in High-Need, Low-Resource Emergency Departments: A Nonrandomized Controlled Trial.Annals of emergency medicine · 2023Article
- Study protocol for a multisite randomized controlled trial of a peer navigator intervention for emergency department patients with nonfatal opioid overdose.Contemporary clinical trials · 2023Article
- Models for Implementing Emergency Department-Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers.Annals of emergency medicine · 2022Article
- Subsequent Buprenorphine Treatment Following Emergency Physician Buprenorphine Prescription Fills: A National Assessment 2019 to 2020.Annals of emergency medicine · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Gail D'OnofrioEmergency Medicine, Yale School of Medicine, New Haven, CT, United States; Yale School of Public Health, New Haven, CT, United States. Electronic address: gail.donofrio@yale.edu.
Kathryn F HawkEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
Andrew A HerringDepartment of Emergency Medicine, Highland Hospital, Oakland, CA, United States.
Jeanmarie PerroneDepartment of Emergency Medicine Perelman, School of Medicine at the University of Pennsylvania, PA, United States.
Ethan CowanDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ryan P McCormackDepartment of Emergency Medicine, NYU Langone Medical Center, New York, NY, United States.
James DziuraEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
R Andrew TaylorEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
Edouard CoupetEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
E Jennifer EdelmanYale School of Public Health, New Haven, CT, United States; Internal Medicine Yale School of Medicine, New Haven, CT, United States.
Michael V PantalonEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
Patricia H OwensEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
Shara H MartelEmergency Medicine, Yale School of Medicine, New Haven, CT, United States.
Patrick G O'ConnorYale School of Public Health, New Haven, CT, United States; Internal Medicine Yale School of Medicine, New Haven, CT, United States.
Paul Van VeldhuisenThe Emmes Corporation, Rockville, MD, United States.
Nicholas DeVogelThe Emmes Corporation, Rockville, MD, United States.
Kristen HuntleyThe National Institute on Drug Abuse, Rockville, MD, United States.
Sean M MurphyWeill Cornell Medical College, NY, New York, United States.
Michelle R LofwallUniversity of Kentucky, College of Medicine Center on Drug and Alcohol Research, Lexington, KY, United States.
Sharon L WalshUniversity of Kentucky, College of Medicine Center on Drug and Alcohol Research, Lexington, KY, United States.
David A FiellinEmergency Medicine, Yale School of Medicine, New Haven, CT, United States; Yale School of Public Health, New Haven, CT, United States; Internal Medicine Yale School of Medicine, New Haven, CT, United States.
Funding
The National Drug Abuse Treatment Clinical Trials NetworkUG1DA015831 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Roger D. Weiss · 2015 to 2026
$110.8MNIDA NIH HHS UG1 DA015831
Abstract
ED-INNOVATION (Emergency Department-INitiated bupreNOrphine VAlidaTION) is a Hybrid Type-1 Implementation-Effectiveness multisite emergency department (ED) study funded through The Helping to End Addiction Long-term
Indexed as
BuprenorphineOpioid-Related DisordersDelayed-Action PreparationsEmergency Service, HospitalHumansNarcotic AntagonistsRandomized Controlled Trials as TopicBuprenorphineDelayed-Action PreparationsNarcotic AntagonistsBuprenorphineEmergency medicineHybrid designImplementation scienceOpioid-related disorders
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.