Evidence map›Paper›PMID 33737170›Full record

Trial reportBrain, behavior, and immunity2021

Effects of web-based cognitive behavioral stress management and health promotion interventions on neuroendocrine and inflammatory markers in men with advanced prostate cancer: A randomized controlled trial.

Frank J Penedo, Rina S Fox, Emily A Walsh, Betina Yanez, Gregory E Miller, Laura B Oswald, Ryne Estabrook, Robert T Chatterton, David C Mohr, Mark J Begale and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  8. Review
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  11. Comorbidity burden and health-related quality of life in men with advanced prostate cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Observational
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Frank J PenedoDepartment of Psychology, University of Miami, United States; Department of Medicine, University of Miami Miller School of Medicine, United States. Electronic address: frank.penedo@miami.edu.
Rina S FoxDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, United States.
Emily A WalshDepartment of Psychology, University of Miami, United States.
Betina YanezDepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, United States.
Gregory E MillerInstitute for Policy Research and Department of Psychology, Northwestern University, United States.
Laura B OswaldHealth Outcomes and Behavior Program, H. Lee Moffitt Cancer Center & Research Institute, United States.
Ryne EstabrookDepartment of Psychology, University of Illinois at Chicago, United States.
Robert T ChattertonDepartment of Obstetrics & Gynecology, Northwestern University Feinberg School of Medicine, United States.
David C MohrDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, United States.
Mark J BegaleVibrent Health, United States.
Sarah C FluryDepartment of Urology, Northwestern University Feinberg School of Medicine, United States.
Kent PerryDepartment of Urology, Northwestern University Feinberg School of Medicine, United States.
Shilajit D KunduDepartment of Urology, Northwestern University Feinberg School of Medicine, United States.
Patricia I MorenoDepartment of Public Health Sciences, University of Miami Miller School of Medicine, United States.
Northwestern University · USUniversity of Miami · USMoffitt Cancer Center · USUniversity of Illinois Chicago · USVidant Health · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Reducing Assessment Barriers for Patients with Low LiteracyR01MD010440 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRIFFITH, JAMES WILLIAM, PAASCHE-ORLOW, MICHAEL · 2017 to 2021
$4.6M
Cancer Prevention, Control, and Survivorship Research Training ProgramT32CA193193 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Brian L Hitsman, BETINA YANEZ · 2015 to 2026
$3.8M
Tele-based Psychosocial Intervention for Symptom Management & HRQOL in Men LivingR01CA157809 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI PENEDO, FRANK J · 2011 to 2016
$2.9M
NCATS NIH HHS UL1 TR001422NCI NIH HHS R01 CA157809NCI NIH HHS T32 CA193193NIMHD NIH HHS R01 MD010440
6 · The paper itself

Abstract

Cognitive behavioral stress management (CBSM) improves quality of life and mitigates stress biology in patients with early-stage cancer, including men with localized prostate cancer. However, treatments for advanced prostate cancer like androgen deprivation therapy (ADT) can lead to significant symptom burden that may be further exacerbated by stress-induced inflammation and cortisol dysregulation. The aim of this study was to examine the effects of CBSM (versus an active health promotion control) on circulating inflammatory markers and cortisol in men with advanced prostate cancer.

methodsMen with stage III or IV prostate cancer (N = 192) who had undergone ADT within the last year were randomized to CBSM or health promotion. Both interventions were 10 weeks, group-based, and delivered online. Venous blood was drawn at baseline, 6 months, and 12 months to measure circulating levels of CRP, IL-6, IL-8, IL-10, and TNF-α. Saliva samples were collected at awakening, 30 min after awakening, evening, and night for two consecutive days at baseline, 6-months, and 12-months to measure diurnal cortisol slopes.

resultsMixed modeling analyses demonstrated that changes in inflammatory markers and cortisol did not differ by intervention. Men in both CBSM and health promotion showed decreases in IL-10, IL-8, and TNF-α from baseline to 6 months (β = -3.85--5.04, p's = 0.004-<0.001). However, these markers generally demonstrated a rebound increase from 6 to 12 months (β = 1.91-4.06, p's = 0.06-<0.001). Men in health promotion also demonstrated a flatter diurnal cortisol slope versus men in CBSM at 6 months (β = -2.27, p = .023), but not at 12 months. There were no intervention effects on CRP, IL-6, or overall cortisol output.

conclusionsContrary to hypotheses, CBSM did not lead to changes in the circulating inflammatory markers and cortisol relative to health promotion. CBSM may be associated with healthy diurnal cortisol rhythm because of its focus on cognitive behavioral approaches to stress management. More research is needed to understand the impact of CBSM and health promotion on biomarkers among men with advanced prostate cancer.

Indexed as

Prostatic NeoplasmsQuality of LifeAndrogen AntagonistsBiomarkersCognitionHealth PromotionHumansHydrocortisoneInternetMaleStress, PsychologicalAndrogen AntagonistsBiomarkersHydrocortisoneAdvanced cancerCognitive behavioral stress managementCortisolInflammationMetastaticProstate cancer

Identifiers

PMID33737170
PMCPMC8888023
OpenAlexW3138841097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.