Evidence map›Paper›PMID 33736997›Full record

Observational studyRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Bioelectrical impedance analysis as a quantitative measure of sarcopenia in head and neck cancer patients treated with radiotherapy.

Aaron J Grossberg, Crosby D Rock, Jared Edwards, Abdallah S R Mohamed, Debra Ruzensky, Angela Currie, Patricia Rosemond, Jack Phan, G Brandon Gunn, Steven J Frank and 4 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Association between different patterns of obesity and the short-term outcomes of gastric cancer surgery.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025
    Article
  3. Review
  4. mEnergy: Development of a Novel mHealth Multi-device Platform for Near Real-time Remote Assessment of Energy Disorders.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Influence of fat-free mass index on the survival of patients with head and neck cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Aaron J GrossbergDepartment of Radiation Medicine, Brenden Colson Center for Pancreatic Care, Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, USA. Electronic address: grossber@ohsu.edu.
Crosby D RockPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA.
Jared EdwardsSchool of Medicine, Oregon Health & Science University, Portland, USA.
Abdallah S R MohamedDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
Debra RuzenskyDepartment of Clinical Nutrition, MD Anderson Cancer Center, Houston, USA.
Angela CurrieDepartment of Clinical Nutrition, MD Anderson Cancer Center, Houston, USA.
Patricia RosemondDepartment of Clinical Nutrition, MD Anderson Cancer Center, Houston, USA.
Jack PhanDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
G Brandon GunnDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
Steven J FrankDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
William H MorrisonDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
Adam S GardenDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
Clifton D FullerDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA.
David I RosenthalDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, USA. Electronic address: dirosenthal@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USOregon Health & Science University · USTexas Tech University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Targeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLS, GORDON B. · 2002 to 2012
$26.1M
Development of functional magnetic resonance imaging-guided adaptive radiotherapy for head and neck cancer patients using novel MR-Linac deviceR01DE028290 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTODOULEAS, JOHN PAUL, FULLER, CLIFTON DAVID · 2019 to 2023
$4.3M
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR01DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2016 to 2020
$2.9M
Hepatic metabolic reprogramming drives pancreatic cancer cachexiaK08CA245188 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI GROSSBERG, AARON · 2020 to 2024
$1.2M
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer TreatmentR01CA214825 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$1.1M
imaging Radiation-Associated Dysphagia (iRAD)R01CA218148 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FULLER, CLIFTON DAVID, HUTCHESON, KATHERINE ARNOLD · 2017 to 2019
$810k
QuBBD: Precision E –Radiomics for Dynamic Big Head & Neck Cancer Data R01CA225190 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$776k
Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)R25EB025787 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAS, PRAJNAN, FULLER, CLIFTON DAVID · 2018 to 2022
$535k
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR56DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2015 to 2015
$470k
NCI NIH HHS K08 CA245188NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA097007NCI NIH HHS R01 CA214825NCI NIH HHS R01 CA218148NCI NIH HHS R01 CA225190NIBIB NIH HHS R25 EB025787NIDCR NIH HHS R01 DE025248NIDCR NIH HHS R01 DE028290NIDCR NIH HHS R56 DE025248
6 · The paper itself

Abstract

background and purposeSarcopenia is associated with decreased survival in head and neck cancer patients treated with radiotherapy. This study sought to determine whether in-clinic multifrequency bioelectrical impedance analysis (BIA) can identify survival-associated sarcopenia in patients with head and neck cancer. MATERIALS AND

methodsThis prospective observational study enrolled 50 patients with head and neck cancer undergoing radiation therapy. Baseline BIA measures of skeletal muscle (SM) mass, fat-free mass (FFM), and fat mass (FM) were compared to CT-based estimates using linear regression. Sex-specific BIA-derived thresholds for sarcopenia were defined by the maximum Youden Index on receiver operator characteristic (ROC) curves. Patients were stratified by sarcopenia status and OS was compared using the Kaplan-Meier method and log-rank test.

resultsAmong 48 evaluable patients, BIA measures of body composition were strongly correlated with CT measures: SM mass (r = 0.97; R

conclusionBIA provides accurate estimates of body composition in head and neck cancer patients. Implementation of BIA in clinical practice may identify patients with sarcopenia at risk for poor survival.

Indexed as

Head and Neck NeoplasmsSarcopeniaBody CompositionBody Mass IndexElectric ImpedanceFemaleHumansMaleMuscle, SkeletalBioelectrical impedance analysisCachexiaHead and neck cancerRadiotherapySarcopenia

Identifiers

PMID33736997
PMCPMC8205950
OpenAlexW3137660025

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.