Evidence map›Paper›PMID 33736706›Full record

ArticleTrials2021

Reshaping the path of vascular cognitive impairment with resistance training: a study protocol for a randomized controlled trial.

Teresa Liu-Ambrose, Elizabeth Dao, Rachel A Crockett, Cindy K Barha, Ryan S Falck, John R Best, Ging-Yeuk R Hsiung, Thalia S Field, Kenneth M Madden, Walid A Alkeridy and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02669394 (Reshaping the Path of Vascular Cognitive Impairment With Resistance Training), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02669394 nacompletednot on this map

Reshaping the Path of Vascular Cognitive Impairment With Resistance Training

TypeinterventionalSponsorUniversity of British ColumbiaRan2016 to 2022Enrolled91ConditionsTransient Ischemic Attack, Vascular Cognitive Impairment, Subcortical Vascular DementiaArmsResistance exercise training, Control: stretching and relaxation program
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  2. 24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada. teresa.ambrose@ubc.ca.ORCID http://orcid.org/0000-0002-8297-5308
Elizabeth DaoDepartment of Radiology, UBC, Vancouver, British Columbia, Canada.
Rachel A CrockettDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Cindy K BarhaDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Ryan S FalckDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
John R BestDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Ging-Yeuk R HsiungDjavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.
Thalia S FieldDjavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.
Kenneth M MaddenCentre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Walid A AlkeridyDivision of Neurology, UBC, Vancouver, British Columbia, Canada.
Narlon C Boa Sorte SilvaDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Jennifer C DavisCentre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Lisanne F Ten BrinkeDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Stephanie DohertyDepartment of Physical Therapy, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Roger C TamDjavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.
University of British Columbia Hospital · CAVancouver Coastal Health · CA

Funding

Heart and Stroke Foundation of Canada G-15-0009019
6 · The paper itself

Abstract

backgroundSubcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Importantly, SIVCI is considered the most treatable form of cognitive impairment in older adults, due to its modifiable risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia. Exercise training is a promising intervention to delay the progression of SIVCI, as it actively targets these cardiometabolic risk factors. Despite the demonstrated benefits of resistance training on cognitive function and emerging evidence suggesting resistance training may reduce the progression of white matter hyperintensities (WMHs), research on SIVCI has predominantly focused on the use of aerobic exercise. Thus, the primary aim of this proof-of-concept randomized controlled trial is to investigate the efficacy of a 12-month, twice-weekly progressive resistance training program on cognitive function and WMH progression in adults with SIVCI. We will also assess the efficiency of the intervention.

methodsEighty-eight community-dwelling adults, aged > 55 years, with SIVCI from metropolitan Vancouver will be recruited to participate in this study. SIVCI will be determined by the presence of cognitive impairment (Montreal Cognitive Assessment < 26) and cerebral small vessel disease using computed tomography or magnetic resonance imaging. Participants will be randomly allocated to a twice-weekly exercise program of (1) progressive resistance training or (2) balance and tone training (i.e., active control). The primary outcomes are cognitive function measured by the Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS-Cog-13 with additional cognitive tests) and WMH progression. DISCUSSION: The burden of SIVCI is immense, and to our knowledge, this will be the first study to quantify the effect of progressive resistance training on cognitive function and WMH progression among adults with SIVCI. Slowing the rate of cognitive decline and WMH progression could preserve functional independence and quality of life. This could lead to reduced health care costs and avoidance of early institutional care.

trial registrationClinicalTrials.gov NCT02669394 . Registered on February 1, 2016.

Indexed as

Cognitive DysfunctionResistance TrainingAgedCognitionExercise TherapyHumansQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeCognitive FunctionExerciseMobilityRandomized controlled trialResistance trainingVascular cognitive impairmentWhite matter hyperintensities

Identifiers

PMID33736706
PMCPMC7971404
OpenAlexW3138927177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.