ArticleBreast cancer research : BCR2021
Risk factors for breast cancer development by tumor characteristics among women with benign breast disease.
Article in Breast cancer research : BCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 42 citations in OpenAlex.
- Breast Cancer Risk After Benign Breast Disease Among Racially Diverse Women: Systematic Review and Meta-Analysis.Research square · 2026Article
- Subsequent breast cancer risk after benign breast biopsy in racially diverse women: Siteman Cancer Center.Journal of the National Cancer Institute · 2026Article
- Multi‑scale immune and spatial profiling of sclerosing adenosis and surrounding breast tissue identifies an immune‑cold field phenotype associated with breast cancer risk.Breast cancer research : BCR · 2026Article
- Relationship of women's breast nodules with lifestyle, mental health and metabolic characteristics: a large, retrospective, longitudinal cohort study.BMC public health · 2026Article
- TransBreastNet a CNN transformer hybrid deep learning framework for breast cancer subtype classification and temporal lesion progression analysis.Scientific reports · 2025Article
- Multimodal analysis of cell-free DNA enhances differentiation of early-stage breast cancer from benign lesions and healthy individuals.BMC biology · 2025Article
- Spatially Resolved Single-Cell Morphometry of Benign Breast Disease Biopsy Images Uncovers Quantitative Cytomorphometric Features Predictive of Subsequent Invasive Breast Cancer Risk.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- Physical Inactivity Amplifies the Link Between Anxiety, Depression, and Neck Pain in Breast Cancer Survivors.Biomedicines · 2025Article
- Deep learning analysis of hematoxylin and eosin-stained benign breast biopsies to predict future invasive breast cancer.JNCI cancer spectrum · 2025Article
- A systematic review of determinants of breast cancer risk among women with benign breast disease.NPJ breast cancer · 2025Article
- Dietary patterns associated with benign breast nodules by subtypes: a cross-sectional study in southeast China.Frontiers in nutrition · 2025Article
- Article
- Infertility treatments and risk of breast benign diseases: a case‒control study.BMC women's health · 2024Article
- The application of methylene blue location technique in deep-seated benign breast tumor resection under endoscopy: a retrospective, single-institution analysis.Gland surgery · 2024Article
- A survey of breastfeeding among women with previous surgery for benign breast disease: a descriptive exploratory study.International breastfeeding journal · 2024Article
- Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease.Breast cancer research : BCR · 2024Article
- Breast Cancer Risk Factors among Women with Solid Breast Lesions.Clinics and practice · 2024Article
- Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era.JAMA surgery · 2024Article
- Multiplicity of benign breast disease lesions and breast cancer risk in African American women.Frontiers in oncology · 2024Article
- Article
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14 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundAmong women diagnosed with invasive breast cancer, 30% have a prior diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD patients that elevate invasive cancer risk. In the general population, risk factors differ in their associations by clinical pathologic features; however, whether women with BBD show etiologic heterogeneity in the types of breast cancers they develop remains unknown.
methodsUsing a nested case-control study of BBD and breast cancer risk conducted in a community healthcare plan (Kaiser Permanente Northwest), we assessed relationships of histologic features in BBD biopsies and patient characteristics with subsequent breast cancer risk and tested for heterogeneity of associations by estrogen receptor (ER) status, tumor grade, and size. The study included 514 invasive breast cancer cases (median follow-up of 9 years post-BBD diagnosis) and 514 matched controls, diagnosed with proliferative or non-proliferative BBD between 1971 and 2006, with follow-up through mid-2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using multivariable polytomous logistic regression models.
resultsBreast cancers were predominantly ER-positive (86%), well or moderately differentiated (73%), small (74% < 20 mm), and stage I/II (91%). Compared to patients with non-proliferative BBD, proliferative BBD with atypia conferred increased risk for ER-positive cancer (OR = 5.48, 95% CI = 2.14-14.01) with only one ER-negative case, P-heterogeneity = 0.45. The presence of columnar cell lesions (CCLs) at BBD diagnosis was associated with a 1.5-fold increase in the risk of both ER-positive and ER-negative tumors, with a 2-fold increase (95% CI = 1.21-3.58) observed among postmenopausal women (56%), independent of proliferative BBD status with and without atypia. We did not identify statistically significant differences in risk factor associations by tumor grade or size.
conclusionMost tumors that developed after a BBD diagnosis in this cohort were highly treatable low-stage ER-positive tumors. CCL in BBD biopsies may be associated with moderately increased risk, independent of BBD histology, and irrespective of ER status.
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