ArticleFluids and barriers of the CNS2021
In vitro evaluation of cerebrospinal fluid velocity measurement in type I Chiari malformation: repeatability, reproducibility, and agreement using 2D phase contrast and 4D flow MRI.
Article in Fluids and barriers of the CNS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- CSF stroke volume measured in pediatric Chiari type 1 Malformation subjects before and after posterior fossa decompression surgery compared with healthy subjects.Fluids and barriers of the CNS · 2026Article
- Moving Past Tonsil Position: Craniocervical Junction Crowding Shapes Cerebrospinal Fluid Effective Motility in Chiari I Malformation.medRxiv : the preprint server for health sciences · 2026Article
- Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.International journal of engineering science · 2026Article
- Association of Posterior Fossa Morphometric Analyses with Cerebrospinal Fluid Flow Parameters in Patients with Chiari Malformation Type 1.Journal of neurological surgery. Part B, Skull base · 2026Article
- Non-invasive assessment of intracranial compliance in idiopathic intracranial hypertension: an MRI-ICP study.Eye (London, England) · 2025Article
- Evaluating amplified magnetic resonance imaging as an input for computational fluid dynamics models of the cerebrospinal fluid.Interface focus · 2025Article
- Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors.Fluids and barriers of the CNS · 2024Article
- Four-dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities.NMR in biomedicine · 2024Review
- Scoliosis in adult Type 1 Chiari malformation with syringomyelia patients: from pathogenesis to treatment.American journal of translational research · 2024Review
- Computational Fluid Dynamics of Cerebrospinal Fluid.Advances in experimental medicine and biology · 2024Review
- Time-Spatial Labeling Inversion Pulse (Time-SLIP) MRI for Evaluating Cerebrospinal Fluid Velocity and Visualizing Flow Dynamics in Patients With Chiari Type I Malformation.Neurosurgery practice · 2023Article
- Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect.bioRxiv : the preprint server for biology · 2023Article
- Article
- Potential association among posterior fossa bony volume and crowdedness, tonsillar hernia, syringomyelia, and CSF dynamics at the craniocervical junction in Chiari malformation type I.Frontiers in neurology · 2023Article
- Quality Control for 4D Flow MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Cerebrospinal fluid dynamics along the optic nerve.Frontiers in neurology · 2022Review
- Computational fluid dynamics model to predict the dynamical behavior of the cerebrospinal fluid through implementation of physiological boundary conditions.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundPhase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics. To improve these diagnostic practices, a better understanding of PC MRI based measurement agreement, repeatability, and reproducibility of CSF dynamics is needed.
methodsAn anatomically realistic in vitro subject specific model of a Chiari malformation patient was scanned three times at five different scanning centers using 2D PC MRI and 4D Flow techniques to quantify intra-scanner repeatability, inter-scanner reproducibility, and agreement between imaging modalities. Peak systolic CSF velocities were measured at nine axial planes using 2D PC MRI, which were then compared to 4D Flow peak systolic velocity measurements extracted at those exact axial positions along the model.
resultsComparison of measurement results showed good overall agreement of CSF velocity detection between 2D PC MRI and 4D Flow (p = 0.86), fair intra-scanner repeatability (confidence intervals ± 1.5 cm/s), and poor inter-scanner reproducibility. On average, 4D Flow measurements had a larger variability than 2D PC MRI measurements (standard deviations 1.83 and 1.04 cm/s, respectively).
conclusionAgreement, repeatability, and reproducibility of 2D PC MRI and 4D Flow detection of peak CSF velocities was quantified using a patient-specific in vitro model of Chiari malformation. In combination, the greatest factor leading to measurement inconsistency was determined to be a lack of reproducibility between different MRI centers. Overall, these findings may help lead to better understanding for application of 2D PC MRI and 4D Flow techniques as diagnostic tools for CSF dynamics quantification in Chiari malformation and related diseases.
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