Evidence map›Paper›PMID 33736650›Full record

ArticlePediatric rheumatology online journal2021

Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort.

Ellen Dalen Arnstad, Mia Glerup, Veronika Rypdal, Suvi Peltoniemi, Anders Fasth, Susan Nielsen, Marek Zak, Kristiina Aalto, Lillemor Berntson, Ellen Nordal and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Ellen Dalen ArnstadDepartment of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Pb 333, 7601, Levanger, Norway. ellen.d.arnstad@ntnu.no.ORCID http://orcid.org/0000-0003-0635-5198
Mia GlerupDepartment of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
Veronika RypdalDepartment of Pediatrics, University Hospital of North Norway and Department of Clinical Medicine, UIT the Arctic University of Norway, Tromsø, Norway.
Suvi PeltoniemiNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, University of Helsinki, Helsinki, Finland.
Anders FasthDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Susan NielsenDepartment of Pediatrics, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Marek ZakDepartment of Pediatrics, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Kristiina AaltoNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, University of Helsinki, Helsinki, Finland.
Lillemor BerntsonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Ellen NordalDepartment of Pediatrics, University Hospital of North Norway and Department of Clinical Medicine, UIT the Arctic University of Norway, Tromsø, Norway.
Troels HerlinDepartment of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
Pål Richard RomundstadDepartment of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Marite RyggDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Nordic Study Group of Pediatric Rheumatology (NoSPeR)
Norwegian University of Science and Technology · NOUniversity Hospital of North Norway · NOCopenhagen University Hospital · DKUniversity of Helsinki · FIUppsala University · SELevanger Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls.

methodsConsecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1-7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used.

resultsAmong 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease-modifying anti-rheumatic drugs (DMARDs)/biologics/systemic steroids. In contrast, participants without these challenges, had fatigue scores similar to controls. Active disease assessed at all three time points (baseline, 8-year and 18-year follow-up) was associated with higher mean fatigue score and higher percentage of severe fatigue compared to disease courses characterized by periods of inactive disease. Predictors of fatigue at the 18-year follow-up were female sex and diagnostic delay of ≥6 months at baseline, and also pain, self-reported poor health, active disease, and previous/ongoing use of DMARDs/biologics at 8 years.

conclusionsFatigue is a prominent symptom in young adults with JIA, with higher fatigue burden among participants with poor sleep, pain, self-reported health problems, active disease, or use of DMARDs/biologics. Participants without these challenges have results similar to controls. Patient- and physician-reported variables at baseline and during disease course predicted fatigue at 18-year follow-up.

Indexed as

AdultArthritis, JuvenileCohort StudiesFatigueFemaleFollow-Up StudiesHumansMaleProspective StudiesScandinavian and Nordic CountriesTime FactorsYoung AdultFatigueHealth-related quality of life (HRQoL)Juvenile idiopathic arthritis (JIA)Long-term outcomesPatient-reported outcomesYoung adults

Identifiers

PMID33736650
PMCPMC7976696
OpenAlexW3139384930

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.