Evidence map›Paper›PMID 33736648›Full record

ArticleBMC complementary medicine and therapies2021

Manasi S Gholkar, Jia V Li, Poonam G Daswani, P Tetali, Tannaz J Birdi

Open access · goldAbstract read
In one paragraph

Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Bioactive Compounds from Guava Leaves (Molecules (Basel, Switzerland) · 2025
    Review
  4. Review
  5. Article
  6. Metabolite Fingerprinting UsingMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Manasi S GholkarDepartment of Medicinal Plants, The Foundation for Medical Research, Dr. Kantilal J. Sheth Memorial Building, 84-A, R.G, Thadani Marg, Worli, Mumbai - 400018, MAHARASHTRA, India.
Jia V LiDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Poonam G DaswaniDepartment of Medicinal Plants, The Foundation for Medical Research, Dr. Kantilal J. Sheth Memorial Building, 84-A, R.G, Thadani Marg, Worli, Mumbai - 400018, MAHARASHTRA, India.
P TetaliPresently Freelance Consultant & Formerly Scientist at Naoroji Godrej Centre for Plant Research (NGCPR), Shirwal, Maharashtra, India.
Tannaz J BirdiDepartment of Medicinal Plants, The Foundation for Medical Research, Dr. Kantilal J. Sheth Memorial Building, 84-A, R.G, Thadani Marg, Worli, Mumbai - 400018, MAHARASHTRA, India. fmr@fmrindia.org.
Foundation for Medical Research · INImperial College London · GB

Funding

Zoetis Pharmaceuticals Private Limited, India Nil
6 · The paper itself

Abstract

backgroundHerbal medicines are fast gaining popularity. However, their acceptability by modern practitioners is low which is often due to lack of standardization. Several approaches towards standardization of herbals have been employed. The current study attempted to recognize key peaks from

methodsNinety samples of guava leaves were collected from three locations over three seasons. Hydroalcoholic (water and ethanol, 50:50) extracts of these samples were prepared and their

resultsOPLS-DA showed seasonal and regional segregation of extracts. Significant models were established for seven bioassays, namely those for anti-bacterial activity against Shigella flexneri and Vibrio cholerae, adherence of E. coli, invasion of E. coli and S. flexneri and production and binding of toxin produced by V. cholerae. It was observed that none of the extracts were good or bad across all the bioassays. The spectral analysis showed multiple peaks correlating with a particular activity. Based on NMR and LC-MS/MS, it was noted that the extracts contained quercetin, ferulic acid and gallic acid. However, they did not correlate with the peaks that segregated extracts with good and poor activity.

conclusionsThe current study identified key peaks in

Indexed as

Magnetic Resonance SpectroscopyAnti-Bacterial AgentsAntidiarrhealsCell Line, TumorChromatography, LiquidHumansPlant ExtractsPlant LeavesPsidiumTandem Mass SpectrometryAnti-Bacterial AgentsAntidiarrhealsPlant Extracts1H NMRIndiaMetabolomicsPsidium guajava

Identifiers

PMID33736648
PMCPMC7977270
OpenAlexW3138191716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.