SynthesisBMC pulmonary medicine2021
Effect of periodontal therapy on COPD outcomes: a systematic review.
Synthesis in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of periodontal therapy on lung function: a twelve-month follow-up intervention study.Respiratory research · 2025Trial
- Advanced Dental Cleaning is Associated with Reduced Risk of COPD Exacerbations - A Randomized Controlled Trial.International journal of chronic obstructive pulmonary diseaseTrial
- Discontinuation of dental care and systemic diseases of persons in need of long-term home care - an observational study from the InSEMaP project with German health insurance claims data.BMC geriatrics · 2026Observational
- Linking lungs and gums: a meta-analysis of periodontitis prevalence and severity in chronic obstructive pulmonary disease.BDJ open · 2026Article
- Association between periodontal disease and chronic obstructive pulmonary disease: an umbrella review.Frontiers in oral health · 2026Review
- From oral infection to pulmonary inflammation: periodontal pathogens and their potential role in COPD susceptibility.Frontiers in cellular and infection microbiology · 2026Article
- Periodontal Pathobionts and Respiratory Diseases: Mechanisms of Interaction and Implications for Interdisciplinary Care.Biomedicines · 2025Review
- Connection between oral health and chronic diseases.MedComm · 2025Review
- Association between Ventilation Disorder and Masticatory Dysfunction in the Korean Adult Population: A Cross-Sectional Study Using Data from the 2019 Korea National Health and Nutrition Examination Survey.Medicina (Kaunas, Lithuania) · 2024Article
- Periodontal disease increases the severity of chronic obstructive pulmonary disease: a Mendelian randomization study.BMC pulmonary medicine · 2024Article
- Comparative analysis of antibodies to four major periodontal bacteria in respiratory diseases: a cohort study.BMJ open · 2024Article
- Advances in the relationship between periodontopathogens and respiratory diseases (Review).Molecular medicine reports · 2024Review
- Unmasking the Silent Threat: Periodontal Health's Impact on COPD Severity and Hospitalization.Journal of personalized medicine · 2023Article
- Associations between Periodontitis and COPD: An Artificial Intelligence-Based Analysis of NHANES III.Journal of clinical medicine · 2022Article
- Transcriptomic analysis reveals pathophysiological relationship between chronic obstructive pulmonary disease (COPD) and periodontitis.BMC medical genomics · 2022Article
- Antimicrobial therapies for prevention of recurrent acute exacerbations of COPD (AECOPD): beyond the guidelines.Respiratory research · 2022Review
- Fusobacterium nucleatum exacerbates chronic obstructive pulmonary disease in elastase-induced emphysematous mice.FEBS open bio · 2022Article
- Periodontitis and Systemic Disorder-An Overview of Relation and Novel Treatment Modalities.Pharmaceutics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLatest evidence suggests that periodontitis is prevalent among patients with chronic obstructive pulmonary disease (COPD), while recent studies have also reported a potential benefit of periodontal treatment on several COPD outcomes. This systematic review aims to determine the impact of periodontal treatment on exacerbation rate, lung function and quality of life of COPD patients.
methodsA systematic search of electronic databases of PubMed, Scopus, Virtual Health Library, ScienceDirect, Wiley Online Library, Web of Science, ProQuest Dissertation and Theses Global and Google Scholar was conducted. Search restricted to studies involving human subjects which were published from January 2000 to March 2020 in English language. Distiller Systematic Review software was used for data management. Risk of bias was assessed using Risk of Bias 2 (RoB2) and Risk of Bias for non-randomized studies of intervention (ROBINS-I) tools. Overall quality of evidence was judged based on Grading of Recommendations Assessment, Development and Evaluation working group methodology.
resultsOut of 1442 articles retrieved, 7 full text articles were included in the review. Limited evidence suggests that periodontal treatment in patients with COPD and periodontitis is associated with reduced exacerbation frequency and a slower lung function decline rate, while its effects on quality of life remain unclear. In addition, periodontal treatment in COPD is associated with lower hospitalization rates and reduced all-cause mortality. Significant methodological differences were noted amongst included studies, while very low-to-moderate overall quality of evidence was demonstrated.
conclusionsAlthough it is reasonable to advise COPD patients not to neglect their dental health, further studies are warranted to determine the role of periodontal therapy on COPD clinical outcomes.
trial registrationPROSPERO 2020 (CRD42020158481). https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020158481.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.