Evidence map›Paper›PMID 33736593›Full record

ArticleBMC genomic data2021

Cloning and expression analysis of GATA1 gene in Carassius auratus red var.

Yusu Tian, Yuandong Sun, Mi Ou, Xiaojuan Cui, Dinggang Zhou, Wen'an Che

Open access · goldAbstract read
In one paragraph

Article in BMC genomic data, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yusu TianHunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life Sciences, Hunan University of Science and Technology, Xiangtan, 411201, Hunan, People's Republic of China.
Yuandong SunHunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life Sciences, Hunan University of Science and Technology, Xiangtan, 411201, Hunan, People's Republic of China. syd@hnust.edu.cn.ORCID 0000-0001-7437-9058
Mi OuKey Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510380, Guangdong, Hunan, People's Republic of China.
Xiaojuan CuiHunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life Sciences, Hunan University of Science and Technology, Xiangtan, 411201, Hunan, People's Republic of China.
Dinggang ZhouHunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life Sciences, Hunan University of Science and Technology, Xiangtan, 411201, Hunan, People's Republic of China.
Wen'an CheHunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization, School of Life Sciences, Hunan University of Science and Technology, Xiangtan, 411201, Hunan, People's Republic of China.
Hunan University of Science and Technology · CNChinese Academy of Fishery Sciences · CN

Funding

Hunan Education Department 17A072Hunan Provincial Science and Technology Department 2019NK4218Scientific Research Project of National Natural Science Foundation of China 31873038State Key Laboratory of Developmental Biology of Freshwater Fish 2018KF008
6 · The paper itself

Abstract

backgroundGATA1 is a key transcription factor in the GATA family, and promotes the differentiation and maturation of red blood cell, which is essential for normal hematopoiesis.

resultsOur results showed that the cDNA sequence of GATA1 was 2730 bp long encoding 443 amino acids. qRT-PCR analysis demonstrated that GATA1 had the highest expression in testis (T), followed by pituitary (P) and spleen (S). GATA1 gene expression in C. auratus red var. embryo from the neuroblast stage (N) to the embryo hatching (H) changes continuously; and the gene expression levels of nonylphenol (NP)-treated and those of control embryos were significantly different. Moreover, Methylation levels of GATA1 gene in NP-treated embryos were higher than those in control embryos, indicating that NP affected GATA1 methylation.

conclusionsOur study provides cues for further studying the roles of GATA1 gene in fish development, and suggested a potential molecular mechanism by which NP leads to abnormal development of fish embryos.

Indexed as

Cloning, MolecularGene Expression ProfilingAnimalsDNA, ComplementaryGATA1 Transcription FactorGoldfishMaleDNA, ComplementaryGATA1 Transcription FactorCarassius auratus red var.,CloningExpression characteristicsGATA1Methylation

Identifiers

PMID33736593
PMCPMC7977614
OpenAlexW3137739732

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.