Evidence map›Paper›PMID 33736479›Full record

ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2022

Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation.

Alejandro Silva Espinosa, Julio Cesar Martinez, Yubahhaline Molina, María Alejandra Bermúdez Gordillo, Daniel Ramos Hernández, Daniela Zárate Rivera, Blanka Pacheco Olmos, Nathaly Ramírez, Liliana Arias, Andres Zarate and 4 more

Abstract read
In one paragraph

Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alejandro Silva EspinosaHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Julio Cesar MartinezHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.ORCID 0000-0003-0704-472X
Yubahhaline MolinaHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
María Alejandra Bermúdez GordilloHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Daniel Ramos HernándezHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Daniela Zárate RiveraHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Blanka Pacheco OlmosHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.ORCID 0000-0001-8314-5958
Nathaly RamírezHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Liliana AriasHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Andres ZarateHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Q Diana Marcela DiazHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.ORCID 0000-0002-6488-9334
Andrew CollinsGenetic Epidemiology & Genomic Informatics, Southampton University, Southampton, UK.
Álvaro Mauricio Herrera Cepeda20313Operation Smile Foundation, Bogota, D.C., Colombia.
Ignacio Briceño BalcazarHuman Genetics Group, 27989Universidad de La Sabana, Chía, Cundinamarca, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the population of patients with cleft lip and/or palate (CL/P) in terms of cleft phenotypes, gender, age, ethnic group, family history, clinical presentation (syndromic vs nonsyndromic), some environmental and behavioral factors, and some clinical features.

designDescriptive retrospective study.

settingPatients attending the genetics counseling practice in Operation Smile Foundation, Bogotá, Colombia, for over 8 years.

participantsNo screening was conducted. All patients requiring clinical genetics assessment in Operation Smile Foundation were included in the study.

resultsLeft cleft lip and palate (CLP) and nonsyndromic forms were the most frequent types of malformations in this population. Psychomotor retardation and heart disease were the most frequent comorbidities in these patients. A low proportion of mothers exposed to passive smoking during pregnancy was observed and low birth weight accounted for an important number of cases. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CLP in this population.

conclusionsIn this study, the most frequent type of CL/P was the nonsyndromic complete left CLP. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CL/P in this population.

Indexed as

Cleft LipCleft PalateColombiaFemaleHumansMothersPregnancyRetrospective Studiesepidemiologymaternal factorsnonsyndromic clefting

Identifiers

PMID33736479
PMCPMC8750128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.