ArticleAmerican journal of human genetics2021
Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia.
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Article in American journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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22 citing papers in PubMed, 30 citations in OpenAlex.
- Disruption of methionine metabolism drives erythroid cell fate reprogramming by remodeling the H3K4me3 landscape.The Journal of clinical investigation · 2026Article
- Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice.Nature biomedical engineering · 2026Article
- New Gene Therapy Strategy for β-Thalassemia.Stem cell reviews and reports · 2026Review
- The mouse resource at National Resource Center for Mutant Mice of China.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.The Journal of clinical investigation · 2025Article
- A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression.Experimental hematology & oncology · 2025Article
- Preclinical efficacy and safety evaluation of BD211 autologous CD34Frontiers in cell and developmental biology · 2025Article
- Efficient andMolecular therapy. Nucleic acids · 2024Article
- The Discovery of Selective Protein Arginine Methyltransferase 5 Inhibitors in the Management of β-Thalassemia through Computational Methods.Molecules (Basel, Switzerland) · 2024Article
- Saracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cells.Human cell · 2024Article
- C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies.Journal of molecular biology · 2024Review
- Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia.Clinical epigenetics · 2024Article
- CRISPR/Cas-based gene editing in therapeutic strategies for beta-thalassemia.Human genetics · 2023Review
- Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.Nature immunology · 2023Article
- In Silico Molecular Docking and Dynamics Simulation Analysis of Potential Histone Lysine Methyl Transferase Inhibitors for Managing β-Thalassemia.Molecules (Basel, Switzerland) · 2023Article
- Review
- The clinical value of hsa-miR-190b-5p in peripheral blood of pediatric β-thalassemia and its regulation on BCL11A expression.PloS one · 2023Article
- Article
- The mouse resource at National Resource Center for Mutant Mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease.Molecular therapy. Methods & clinical development · 2021Review
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Authors and funding
26 authors at 15 institutions in 3 countries.
Xiuqin BaoDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Xinhua ZhangDepartment of Hematology, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021, China.
Liren WangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Zhongju WangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Jin HuangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Qianqian ZhangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Yuhua YeDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Yongqiong LiuDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Diyu ChenDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Yangjin ZuoDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China.
Qifa LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangzhou 510515, China.
Peng XuHematology Center of Cyrus Tang Medical Institute, Soochow University, Suzhou 215123, China.
Binbin HuangDepartment 1 of Internal Medicine, Sixth People's Hospital of Nanning, Nanning, Guangxi 530021, China.
Jianpei FangDepartment of Pediatrics, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, 510120 Guangdong, China.
Jinquan LaoDepartment of Pediatrics, Liuzhou Worker's Hospital, Liuzhou, Guangxi 545005, China.
Xiaoqin FengDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 Guangdong, China.
Yafeng LiDepartment of Nephrology, The Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China; Precision Medicine Center, The Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.
Ryo KuritaDepartment of Research and Development, Central Blood Institute, Japanese Red Cross Society, Shibadaimon, Minato-ku, Tokyo 105-8521, Japan.
Yukio NakamuraCell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan; Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Weiwei YuGemPharmatech Co., Ltd., Nanjing 210000, Jiangsu, China.
Cunxiang JuGemPharmatech Co., Ltd., Nanjing 210000, Jiangsu, China.
Chunbo HuangGuangzhou Huayin Medical Laboratory Center Co., Ltd., Guangzhou, 510663 Guangdong, China; Guangzhou Jiexu Gene Technology Co., Ltd., Guangzhou, 510530 Guangdong, China.
Narla MohandasRed Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA.
Dali LiShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Cunyou ZhaoDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China. Electronic address: cyzhao@smu.edu.cn.
Xiangmin XuDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Molecular Diagnostics of Human Genetic Diseases, Guangzhou, 510515 Guangdong, China; Guangdong Engineering and Technology Research Center for Genetic Testing, Guangzhou, 510515 Guangdong, China. Electronic address: gzxuxm@pub.guangzhou.gd.cn.
Southern Medical University · CNKey Laboratory of Guangdong Province · CNEast China Normal University · CN303 Hospital of People's Liberation Army · CNChina Guangzhou Analysis and Testing Center · CNFourth Affiliated Hospital of Guangxi Medical University · CNJapanese Red Cross Society, Japan · JPJinyintan Hospital · CNNanfang Hospital · CNNew York Blood Center · USShaanxi Provincial People's Hospital · CNSoochow University · CNSun Yat-sen University · CNThe Second Nanning People's Hospital · CNUniversity of Tsukuba · JP
Funding
YEAST MEMBRANE CYTOSKELETONP01DK032094 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NARLA, MOHANDAS · 1987 to 2021
$26.7MNIDDK NIH HHS P01 DK032094
Abstract
The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health problems. Although significant progress has been made in our understanding of the molecular mechanism of the fetal-to-adult hemoglobin switch, the mechanism of epigenetic regulation of HbF silencing remains to be fully defined. Here, we performed whole-genome bisulfite sequencing and RNA sequencing analysis of the bone marrow-derived GYPA
Indexed as
Epigenesis, GeneticGene Expression ProfilingAnimalsAntigens, CD34Base Sequencebeta-ThalassemiaCell DifferentiationCell LineChildCRISPR-Cas SystemsDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AErythroid Precursor CellsFemaleFetal HemoglobinAntigens, CD34DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseERF protein, humanFetal Hemoglobingamma-Globinshydrogen sulfiteRepressor ProteinsSulfitesCD34+ HSPCsengraftment miceepigeneticsERFfetal hemoglobingenome editingGYPA+ cellsmethylationwhole-genome bisulfite sequencingβ-thalassemia
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