Trial reportAnnals of the American Thoracic Society2021
Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials.
Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Annals of the American Thoracic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Efficacy of iron replacement in pulmonary hypertension: A systematic review.Nutrition and health · 2025Pooled it
- Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Iron Compartmentalisation and Vascular Endothelial Cell Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
- Iron Deficiency in Pulmonary Hypertension-Prevalence, Impact on Prognosis and Disease Burden in Pulmonary Arterial Hypertension and Pulmonary Hypertension Related to Hypoxia: A Review.International journal of molecular sciences · 2026Review
- Reduced gastrointestinal iron uptake in pulmonary arterial hypertension: a prospective cross-sectional study.Respiratory research · 2026Article
- Sotatercept for the treatment of portopulmonary hypertension: a case report.Communications medicine · 2026Article
- Addressing micronutrient deficiencies and vitamin metabolism disorders in pediatric pulmonary hypertension: a strategic proposal for low- and middle-income countries.Frontiers in cardiovascular medicine · 2026Review
- Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape.Expert opinion on therapeutic targets · 2025Review
- Clinical and prognostic significance of various anemia types in pulmonary arterial hypertension.Frontiers in medicine · 2025Article
- Oxygen-sensing pathways and the pulmonary circulation.The Journal of physiology · 2024Review
- The Role of Early Child Nutrition in Pulmonary Hypertension-A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Immature reticulocyte fraction: A novel biomarker of hemodynamic severity in pulmonary arterial hypertension.Pulmonary circulation · 2024Article
- Iron deficiency and supplementation in heart failure.Nature reviews. Cardiology · 2024Review
- The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?Cardiovascular toxicology · 2024Article
- Intravenous iron supplementation in pulmonary hypertension groups 1 to 4.International journal of medical sciences · 2024Article
- A hypothesis: Potential contributions of metals to the pathogenesis of pulmonary artery hypertension.Life sciences · 2024Review
- Connective tissue disease-associated pulmonary hypertension: A comprehensive review.Pulmonary circulation · 2023Review
- Evaluation of a pharmacist-provider collaborative clinic for treatment of iron deficiency in patients with heart failure.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023Article
- Redefining both iron deficiency and anaemia in cardiovascular disease.European heart journal · 2023Article
- Medical Management of Pulmonary Arterial Hypertension: Current Approaches and Investigational Drugs.Pharmaceutics · 2023Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
28 authors at 7 institutions in 4 countries.
Luke S G E HowardNational Heart and Lung Institute and.
Jianguo HeCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Geoffrey M J WatsonNational Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom.
Li HuangCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
John WhartonNational Heart and Lung Institute and.
Qin LuoCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
David G KielyDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Robin CondliffeNational Pulmonary Hypertension Service, Sheffield Pulmonary Vascular Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Joanna Pepke-ZabaNational Pulmonary Hypertension Service, Royal Papworth Hospital, Cambridge, United Kingdom.
Nicholas W MorrellNational Pulmonary Hypertension Service, Royal Papworth Hospital, Cambridge, United Kingdom.
Karen K ShearesNational Pulmonary Hypertension Service, Royal Papworth Hospital, Cambridge, United Kingdom.
Anna UlrichNational Heart and Lung Institute and.
Ruilin QuanCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhihui ZhaoCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiaoli JingCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chenhong AnCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhihong LiuCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Changming XiongCenter of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Peter A RobbinsDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Timothy DawesNational Heart and Lung Institute and.
Antonio de MarvaoMedical Research Council London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
Christopher J RhodesNational Heart and Lung Institute and.
Manuel J RichterDepartment of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (Deutsches Zentrum für Lungenforschung), Giessen, Germany; and.
Henning GallDepartment of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (Deutsches Zentrum für Lungenforschung), Giessen, Germany; and.
Hossein A GhofraniNational Heart and Lung Institute and.
Lan ZhaoNational Heart and Lung Institute and.ORCID 0000-0003-1177-5568
Les HusonNational Heart and Lung Institute and.
Martin R WilkinsNational Heart and Lung Institute and.ORCID 0000-0003-3926-1171
Chinese Academy of Medical Sciences & Peking Union Medical College · CNLung Institute · USJustus-Liebig-Universität Gießen · DEPapworth Hospital · GBNational Health Service · GBRoyal Hallamshire Hospital · GBMRC London Institute of Medical Sciences · GB
Funding
British Heart Foundation CH/09/001/25945British Heart Foundation FS/15/59/31839British Heart Foundation PG/18/2/33446British Heart Foundation RG/10/16/28575Medical Research Council MC_UP_1102/19
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anemia, Iron-DeficiencyPulmonary Arterial HypertensionCross-Over StudiesDietary SupplementsDouble-Blind MethodFamilial Primary Pulmonary HypertensionHumansIronTreatment OutcomeIronexercise capacityferric carboxymaltoseironiron dextranpulmonary arterial hypertension
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.