ArticlePsychiatry investigation2021
Early Trauma Is Associated with Poor Pharmacological Treatment Response in Patients with Panic Disorder.
Article in Psychiatry investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Poor Treatment Response in Panic Disorder Patients with Suicide Attempts and Their Symptom Network Characteristics.Depression and anxiety · 2023Article
- Structural Features Predict Sexual Trauma and Interpersonal Problems in Borderline Personality Disorder but Not in Controls: A Multi-Voxel Pattern Analysis.Frontiers in human neuroscience · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
objectivePharmacotherapy is established as an effective method for reducing symptoms of panic disorder (PD). However, about 20-40% of PD patients are treatment-resistant. Predictors of pharmacotherapy outcomes for PD patients are needed.
methodsThis study included 152 PD patients to measure the clinical severities of PD symptoms and used the Early Trauma Inventory (ETI) to measure early trauma. Treatment response was defined as a 40% reduction in the total Panic Disorder Severity Scale score from baseline. We measured the treatment responses at 8 weeks and 6 months. Binary logistic regression was used to predict treatment response after controlling for confounding variables.
resultsEarly sexual trauma alone was associated with poor treatment response at 8 weeks. However, at 6 months, the total ETI score was associated with an unfavorable treatment response.
conclusionTherefore, our study suggests that clinicians need to be aware of a history of early trauma to optimize treatment outcomes for PD patients.
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