Evidence map›Paper›PMID 33735485›Full record

ArticleCancer science2021

Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer.

Takuya Mori, Hiroaki Tanaka, Shugo Suzuki, Sota Deguchi, Yoshihito Yamakoshi, Mami Yoshii, Yuichiro Miki, Tatsuro Tamura, Takahiro Toyokawa, Shigeru Lee and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 5 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 5 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Infection and immunity · 2025
    Article
  19. Review
  20. An Introduction to Tertiary Lymphoid Structures in Cancer.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Takuya MoriDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0002-0188-1116
Hiroaki TanakaDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0001-7301-1112
Shugo SuzukiDepartment of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Sota DeguchiDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yoshihito YamakoshiDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Mami YoshiiDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Yuichiro MikiDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Tatsuro TamuraDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Takahiro ToyokawaDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Shigeru LeeDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kazuya MugurumaDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Hideki WanibuchiDepartment of Molecular Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Masaichi OhiraDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Osaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have reported that tissue-resident memory T cells (TRM cells) or tertiary lymphoid structures (TLSs) are associated with a good prognosis. The aim of this study was to clarify the association of TRM cells and TLSs in the tumor immune microenvironment in gastric cancer (GC). We performed immunohistochemical and immunofluorescence staining to detect the presence of CD103

Indexed as

Antigens, CDIntegrin alpha ChainsAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleGranzymesHumansImmune Checkpoint InhibitorsImmunity, CellularInterferon-gammaKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMalePrognosisProgrammed Cell Death 1 Receptoralpha E integrinsAntigens, CDGranzymesGZMB protein, humanImmune Checkpoint InhibitorsIntegrin alpha ChainsInterferon-gammaPDCD1 protein, humanProgrammed Cell Death 1 Receptorantitumor immunityCD103gastric cancertertiary lymphoid structuretissue-resident memory T cell

Identifiers

PMID33735485
PMCPMC8088970
OpenAlexW3139219537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.