Evidence map›Paper›PMID 33735480›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2021

Early detection of SARS-CoV-2 and other infections in solid organ transplant recipients and household members using wearable devices.

Brendan J Keating, Eyas H Mukhtar, Eric D Elftmann, Feyisope R Eweje, Hui Gao, Lina I Ibrahim, Ranganath G Kathawate, Alexander C Lee, Eric H Li, Krista A Moore and 35 more

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06161454 (A Feasibility Study of Xofluza Treatment of Influenza in Pediatric Transplant Recipients, Waitlisted Subjects and Household Members After Early Infection Alerting Using Wearable Devices), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06161454 phase4completednot on this mapstarted 2023, after this paper: background citation

A Feasibility Study of Xofluza Treatment of Influenza in Pediatric Transplant Recipients, Waitlisted Subjects and Household Members After Early Infection Alerting Using Wearable Devices

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2023 to 2025Enrolled498ConditionsInfection, Coronavirus, Infections, Influenza, TransplantArmsBaloxavir Marboxil
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 13 institutions in 3 countries.

Brendan J KeatingDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.ORCID 0000-0002-3320-3723
Eyas H MukhtarDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Eric D ElftmannDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Feyisope R EwejeDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Hui GaoDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Lina I IbrahimDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Ranganath G KathawateDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Alexander C LeeDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Eric H LiDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Krista A MooreDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Nikhil NairDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Venkata ChaluvadiDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Janaiya ReasonDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Francesca ZanoniDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Alexander T HonkalaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Amein K Al-AliDepartment of Clinical Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Fatima Abdullah AlrubaishDepartment of Internal Medicine, King Fahd Hospital of The University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia.
Maha Ahmad Al-MozainiImmunocompromised Host Research, Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Fahad A Al-MuhannaDepartment of Internal Medicine, King Fahd Hospital of The University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia.
Khaldoun Al-RomaihNational Centre of Genomic Technology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Samuel B GoldfarbDivision of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ryan KelloggDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Krzysztof KirylukDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Sarah J KizilbashDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Taisa J KohutDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Juhi KumarWeill Cornell Medical College, New York, NY, USA.
Matthew J O'ConnorDivision of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elizabeth B RandDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert R RedfieldDivision of Transplantation, Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Benjamin RolnikDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Joseph RossanoDivision of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pablo G SanchezDivision of Lung Transplant and Lung Failure, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Arash AlaviDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Amir BahmaniDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Gireesh K BoguDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Andrew W BrooksDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Ahmed A MetwallyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Tejas MishraDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Stephen D MarksGreat Ormond Street Hospital for Children, NHS Foundation Trust London, London, UK.
Robert A MontgomeryNew York University Langone Transplant Institute, New York, NY, USA.
Jay A FishmanTransplant Infectious Disease Program, Infectious Disease Division, and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sandra AmaralDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pamala A JacobsonDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Meng WangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
University of Pennsylvania · USStanford University · USChildren's Hospital of Philadelphia · USColumbia University · USKing Fahd Hospital of the University · SAKing Faisal Specialist Hospital & Research Centre · SAUniversity of Minnesota · USCornell University · USGreat Ormond Street Hospital · GBHarvard University · USImam Abdulrahman Bin Faisal University · SANew York University · USUniversity of Pittsburgh Medical Center · US

Funding

VIRTUUS Children's Study: Validating Injury to the Renal Transplant Using Urinary Signatures in ChildrenR01HD091185 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI AMARAL, SANDRA, KEATING, BRENDAN JAMES · 2017 to 2021
$3.4M
Training Program in the Genetic Basis of Pediatric Gastrointestinal DisordersT32DK101371 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERT O HEUCKEROTH, Judith Rachel Kelsen · 2014 to 2026
$2.5M
Gut Bacteriophage Correspondence with Inflammation and Clinical Dietary InterventionsF32DK126287 · NIDDK · STANFORD UNIVERSITY · PI BROOKS, ANDREW WALLACE · 2021 to 2023
$205k
NICHD NIH HHS R01 HD091185NIDDK NIH HHS F32 DK126287NIDDK NIH HHS T32 DK101371
6 · The paper itself

Abstract

The increasing global prevalence of SARS-CoV-2 and the resulting COVID-19 disease pandemic pose significant concerns for clinical management of solid organ transplant recipients (SOTR). Wearable devices that can measure physiologic changes in biometrics including heart rate, heart rate variability, body temperature, respiratory, activity (such as steps taken per day) and sleep patterns, and blood oxygen saturation show utility for the early detection of infection before clinical presentation of symptoms. Recent algorithms developed using preliminary wearable datasets show that SARS-CoV-2 is detectable before clinical symptoms in >80% of adults. Early detection of SARS-CoV-2, influenza, and other pathogens in SOTR, and their household members, could facilitate early interventions such as self-isolation and early clinical management of relevant infection(s). Ongoing studies testing the utility of wearable devices such as smartwatches for early detection of SARS-CoV-2 and other infections in the general population are reviewed here, along with the practical challenges to implementing these processes at scale in pediatric and adult SOTR, and their household members. The resources and logistics, including transplant-specific analyses pipelines to account for confounders such as polypharmacy and comorbidities, required in studies of pediatric and adult SOTR for the robust early detection of SARS-CoV-2, and other infections are also reviewed.

Indexed as

COVID-19Organ TransplantationWearable Electronic DevicesAdultChildHumansPandemicsSARS-CoV-2eHealthmHealthtelemedicinetransplantationwearables

Identifiers

PMID33735480
PMCPMC8250335
OpenAlexW3137986574

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.