ReviewEuropean journal of nuclear medicine and molecular imaging2021
Applicability, potential and limitations of TSPO PET imaging as a clinical immunopsychiatry biomarker.
Review in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- EANM perspective on clinical PET and SPECT imaging in schizophrenia-spectrum disorders: a systematic review of longitudinal studies.European journal of nuclear medicine and molecular imaging · 2025Pooled it
- The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis.Molecular psychiatry · 2022Pooled it
- BrainFrontiers in immunology · 2021Pooled it
- Network-based disease fingerprinting with neuroinflammation PET imaging.Journal of neuroinflammation · 2026Article
- Molecular and Neuroimaging Correlates of Bipolar Disorder: Linking Inflammation, Mitochondria, and Brain Circuitry.International journal of molecular sciences · 2026Review
- Host-directed nanotherapy for the treatment and imaging of tuberculous meningitis.Theranostics · 2026Article
- Network-based disease fingerprinting with neuroinflammation PET imaging.Research square · 2025Article
- PET imaging of neuroinflammation: any credible alternatives to TSPO yet?Molecular psychiatry · 2025Review
- Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Systemic inflammatory biomarkers in Schizophrenia are changed by ECT administration and related to the treatment efficacy.BMC psychiatry · 2024Article
- Microglial Positron Emission Tomography Imaging In Vivo : Positron Emission Tomography Radioligands: Utility in Research and Clinical Practice.Advances in neurobiology · 2024Review
- A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging.Frontiers in neuroscience · 2024Article
- Specific feature recognition on group specific networks (SFR-GSN): a biomarker identification model for cancer stages.Frontiers in genetics · 2024Article
- Characterization of the Novel P2X7 Receptor Radioligand [ACS chemical neuroscience · 2023Article
- Article
- PET imaging of retinal inflammation in mice exposed to blue light using [Molecular vision · 2023Article
- Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method.Diagnostics (Basel, Switzerland) · 2022Article
- PET imaging of retinal inflammation in mice exposed to blue light using [Molecular vision · 2022Article
- Advances in PET imaging of ischemic stroke.Frontiers in stroke · 2022Review
- Imaging translocator protein expression with positron emission tomography.European journal of nuclear medicine and molecular imaging · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTSPO PET imaging may hold promise as a single-step diagnostic work-up for clinical immunopsychiatry. This review paper on the clinical applicability of TSPO PET for primary psychiatric disorders discusses if and why TSPO PET imaging might become the first clinical immunopsychiatry biomarker and the investment prerequisites and scientific advancements needed to accommodate this transition from bench to bedside.
methodsWe conducted a systematic search of the literature to identify clinical studies of TSPO PET imaging in patients with primary psychiatric disorders. We included both original case-control studies as well as longitudinal cohort studies of patients with a primary psychiatric diagnosis.
resultsThirty-one original studies met our inclusion criteria. In the field of immunopsychiatry, TSPO PET has until now mostly been studied in schizophrenia and related psychotic disorders, and to a lesser extent in mood disorders and neurodevelopmental disorders. Quantitative TSPO PET appears most promising as a predictive biomarker for the transdiagnostic identification of subgroups or disease stages that could benefit from immunological treatments, or as a prognostic biomarker forecasting patients' illness course. Current scanning protocols are still too unreliable, impractical and invasive for clinical use in symptomatic psychiatric patients.
conclusionTSPO PET imaging in its present form does not yet offer a sufficiently attractive cost-benefit ratio to become a clinical immunopsychiatry biomarker. Its translation to psychiatric clinical practice will depend on the prioritising of longitudinal research and the establishment of a uniform protocol rendering clinically meaningful TSPO uptake quantification at the shortest possible scan duration without arterial cannulation.
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