ArticleThe Journal of infectious diseases2021
Antioxidants Associated With Oncogenic Human Papillomavirus Infection in Women.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- The mediating role of BMI in the association between composite dietary antioxidant index and infertility in women: a nationwide population-based study.BMC women's health · 2025Article
- The Role of Nutrition in HPV Infection and Cervical Cancer Development: A Review of Protective Dietary Factors.Cancers · 2025Review
- Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/-) Cervical Cancer.Journal of medical virology · 2025Review
- The dietary inflammatory index (DIIBMC public health · 2024Article
- Emerging paradigms: unmasking the role of oxidative stress in HPV-induced carcinogenesis.Infectious agents and cancer · 2024Review
- Vitamins in Gynecologic Malignancies.Nutrients · 2024Review
- Association between Serum Folate and Vaginal High-Risk Human Papillomavirus Infections in United States Women.The Journal of nutrition · 2024Article
- Article
- Serum oxidative biomarkers associated with genital HPV infection and cervical lesions in women.Journal of medical virology · 2024Article
- Healthy lifestyle and HPV infection risk: results from a cross-sectional study.Frontiers in public health · 2024Article
- Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review.Frontiers in nutrition · 2024Review
- Article
- Impact of Dietary Quality on Genital Oncogenic Human Papillomavirus Infection in Women.The Journal of infectious diseases · 2023Article
- Human papillomavirus associated cervical lesion: pathogenesis and therapeutic interventions.MedComm · 2023Review
- Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- ROS regulation in gliomas: implications for treatment strategies.Frontiers in immunology · 2023Review
- Fermented Mangosteen (Cancers · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHuman papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed the onset of HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The association between antioxidants and oncogenic HPV remains unclear. In this study, we aim to identify antioxidants associated with vaginal HPV infection in women.
methodsThe associations between the 15 antioxidants and vaginal HPV infection status (no, low-risk [LR], and high-risk [HR] HPV) were evaluated using 11 070 women who participated in the 2003-2016 National Health and Nutrition Examination Survey (NHANES).
resultsWe identified serum albumin and 4 dietary antioxidants (vitamin A, B2, E, and folate) inversely associated with HR-HPV infection. Women with a low level of albumin (≤39 g/L) have a significantly higher risk of HR-HPV (odds ratio [OR] = 1.4, P = .009 vs >44 g/L). A Nutritional Antioxidant Score (NAS) was developed based on these 4 dietary antioxidants. The women with the lowest quartile NAS had a higher chance of HR-HPV (OR = 1.3, P = .030) and LR-HPV (OR = 1.4, P = .002) compared with the women with the highest quartile NAS.
conclusionsWe identified 5 antioxidants negatively associated with vaginal HR-HPV infection in women. Our findings provide valuable insights into understanding antioxidants' impact on HPV carcinogenesis.
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Registered trials
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