Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors at 3 institutions in 1 country.
Lucas Dos Santos DiasDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-2344-1354
Hannah E DobsonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-1246-880X
Brock Kingstad BakkeDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Gregory C KujothDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-6636-2800
Junfeng HuangSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-1672-3751
Elaine M KohnDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Cleison Ledesma TairaDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Huafeng WangDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Nitin T SupekarComplex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0002-7006-7177
J Scott FitesDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-4294-730X
Daisy GatesDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Christina L GomezDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Charles A SpechtDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.ORCID 0000-0002-5749-3112
Stuart M LevitzDepartment of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.ORCID 0000-0002-3799-3064
Parastoo AzadiComplex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0002-6166-9432
Lingjun LiSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-0056-3869
Marulasiddappa SureshDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-1794-3358
Bruce S KleinDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-3212-1539
Marcel WüthrichDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-2781-7876
University of Wisconsin–Madison · USUniversity of Massachusetts Chan Medical School · USUniversity of Georgia · US
Funding
PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
ROLE OF MACROPHAGES IN CRYPTOCOCCAL INFECTIONSR01AI025780 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 1987 to 2019
$7.1M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
Novel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell MemoryU01AI124299 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, SURESH, MARULASIDDAPPA · 2016 to 2025
$6.2M
National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
Regulation of vaccine-induced anti-fungal Th17 cellsR01AI093553 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WUETHRICH, MARCEL · 2011 to 2020
$4.5M
MOLECULAR PATHOGENESIS OF BLASTOMYCOSISR01AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 1995 to 2019
$3.9M
Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's diseaseRF1AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$2.4M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
Lung epithelial cell regulation of immunity to inhaled fungiR01AI130411 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2018 to 2021
$2.0M
MULTIPLEX CHEMICAL TAGS FOR HIGH-THROUGHPUT GLYCAN AND GLYCOPEPTIDE QUANTITATION AND CHARACTERIZATIONU01CA231081 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2020
$1.3M
Orbitrap Fusion Tribrid Mass SpectrometerS10OD018530 · OD · UNIVERSITY OF GEORGIA · PI AZADI, PARASTOO · 2014 to 2014
The development of safe subunit vaccines requires adjuvants that augment immunogenicity of non-replicating protein-based antigens. Current vaccines against infectious diseases preferentially induce protective antibodies driven by adjuvants such as alum. However, the contribution of antibody to host defense is limited for certain classes of infectious diseases such as fungi, whereas animal studies and clinical observations implicate cellular immunity as an essential component of the resolution of fungal pathogens. Here, we decipher the structural bases of a newly identified glycoprotein ligand of Dectin-2 with potent adjuvancy, Blastomyces endoglucanase-2 (Bl-Eng2). We also pinpoint the developmental steps of antigen-specific CD4+ and CD8+ T responses augmented by Bl-Eng2 including expansion, differentiation and tissue residency. Dectin-2 ligation led to successful systemic and mucosal vaccination against invasive fungal infection and Influenza A infection, respectively. O-linked glycans on Bl-Eng2 applied at the skin and respiratory mucosa greatly augment vaccine subunit- induced protective immunity against lethal influenza and fungal pulmonary challenge.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity. · full record | OpenQuestion