Evidence map›Paper›PMID 33734600›Full record

ReviewJournal of cellular and molecular medicine2021

Back to basics in COVID-19: Antigens and antibodies-Completing the puzzle.

Monica Neagu, Daniela Calina, Anca Oana Docea, Carolina Constantin, Tommaso Filippini, Marco Vinceti, Nikolaos Drakoulis, Konstantinos Poulas, Taxiarchis Konstantinos Nikolouzakis, Demetrios A Spandidos and 1 more

Abstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. The parallel lives of pandemics: COVID‑19 and obesity.Experimental and therapeutic medicine · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Experimental and therapeutic medicine · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Seroprevalence of anti-SARS-CoV-2 antibodies in the Northern Italy population before the COVID-19 second wave.International journal of occupational medicine and environmental health · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Testing Antigens, Antibodies, and Immune Cells in COVID-19 as a Public Health Topic-Experience and Outlines.International journal of environmental research and public health · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monica NeaguDepartment of Immunology, Victor Babes National Institute of Pathology, Bucharest, Romania.ORCID 0000-0001-9339-2805
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Carolina ConstantinDepartment of Immunology, Victor Babes National Institute of Pathology, Bucharest, Romania.
Tommaso FilippiniSection of Public Health, Department of Biomedical, Metabolic and Neural Sciences, Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0003-2100-0344
Marco VincetiSection of Public Health, Department of Biomedical, Metabolic and Neural Sciences, Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), University of Modena and Reggio Emilia, Modena, Italy.
Nikolaos DrakoulisResearch Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Phrarmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos PoulasDepartment of Pharmacy, Laboratory of Molecular Biology and Immunology, University of Patras, Patras, Greece.
Taxiarchis Konstantinos NikolouzakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, Greece.
Demetrios A SpandidosLaboratory of Clinical Virology, Medical School, University of Crete, Heraklion, Greece.
Aristidis TsatsakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, Greece.

Funding

NASR PN 19.29.01.01Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.2-PCCDI-2017-0341/2018
6 · The paper itself

Abstract

The outbreak of the coronavirus disease 2019 (COVID-19) has gathered 1 year of scientific/clinical information. This informational asset should be thoroughly and wisely used in the coming year colliding in a global task force to control this infection. Epidemiology of this infection shows that the available estimates of SARS-CoV-2 infection prevalence largely depended on the availability of molecular testing and the extent of tested population. Within molecular diagnosis, the viability and infectiousness of the virus in the tested samples should be further investigated. Moreover, SARS-CoV-2 has a genetic normal evolution that is a dynamic process. The immune system participates to the counterattack of the viral infection by pathogen elimination, cellular homoeostasis, tissue repair and generation of memory cells that would be reactivated upon a second encounter with the same virus. In all these stages, we still have knowledge to be gathered regarding antibody persistence, protective effects and immunological memory. Moreover, information regarding the intense pro-inflammatory action in severe cases still lacks and this is important in stratifying patients for difficult to treat cases. Without being exhaustive, the review will cover these important issues to be acknowledged to further advance in the battle against the current pandemia.

Indexed as

COVID-19COVID-19 TestingSARS-CoV-2AnimalsAntibodies, ViralAntigens, ViralHumansImmunologic MemoryMutationPandemicsAntibodies, ViralAntigens, Viralantibodiesantigensimmune memoryimmune responsemutationsSARS-CoV-2tests

Identifiers

PMID33734600
PMCPMC8107083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.