ArticleHuman brain mapping2021
Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Mild and repetitive mild traumatic brain injury: Changes in microglial cells and synapses.Neural regeneration research · 2026Article
- Younger Age of First Exposure to American Football Is Associated with Worse Informant-Reported Clinical Outcomes in Older Age Brain Donors.Journal of neurotrauma · 2026Article
- Comparison of Six Data Cleaning Methods for Determining Repetitive Head Impact Exposure in Youth Tackle Football.Annals of biomedical engineering · 2026Article
- Neural Efficiency and Sensorimotor Adaptations in Swimming Athletes: A Systematic Review of Neuroimaging and Cognitive-Behavioral Evidence for Performance and Wellbeing.Brain sciences · 2026Review
- Correlating Magnetoencephalography, Diffusion Kurtosis Imaging, Biomechanics, and Neuropsychology in American Youth Football.Journal of neurotrauma · 2025Article
- A Comparative Neuroimaging Review of Repetitive Head Impacts and Mild Traumatic Brain Injury from Pediatrics to Professionals.Neurotrauma reports · 2025Review
- High-magnitude headers are not associated with structural and functional brain changes in active high-level football (soccer) players.BMJ open sport & exercise medicine · 2025Article
- Longitudinal changes in resting state fMRI brain self-similarity of asymptomatic high school American football athletes.Scientific reports · 2024Article
- Cognitive and cortical network alterations in pediatric temporal lobe space-occupying lesions: an fMRI study.Frontiers in human neuroscience · 2024Article
- Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study.Frontiers in neurology · 2024Article
- Repetitive subconcussion results in disrupted neural activity independent of concussion history.Brain communications · 2024Article
- Subconcussive changes in youth football players: objective evidence using brain vital signs and instrumented accelerometers.Brain communications · 2022Article
- Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Repetitive head impact (RHI) exposure in collision sports may contribute to adverse neurological outcomes in former players. In contrast to a concussion, or mild traumatic brain injury, "subconcussive" RHIs represent a more frequent and asymptomatic form of exposure. The neural network-level signatures characterizing subconcussive RHIs in youth collision-sport cohorts such as American Football are not known. Here, we used resting-state functional MRI to examine default mode network (DMN) functional connectivity (FC) following a single football season in youth players (n = 50, ages 8-14) without concussion. Football players demonstrated reduced FC across widespread DMN regions compared with non-collision sport controls at postseason but not preseason. In a subsample from the original cohort (n = 17), players revealed a negative change in FC between preseason and postseason and a positive and compensatory change in FC during the offseason across the majority of DMN regions. Lastly, significant FC changes, including between preseason and postseason and between in- and off-season, were specific to players at the upper end of the head impact frequency distribution. These findings represent initial evidence of network-level FC abnormalities following repetitive, non-concussive RHIs in youth football. Furthermore, the number of subconcussive RHIs proved to be a key factor influencing DMN FC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.