Evidence map›Paper›PMID 33734452›Full record

Trial reportBiopharmaceutics & drug disposition2021

Prediction of a clinically effective dose of THY1773, a novel V

Shoko Inatani, Akiko Mizuno-Yasuhira, Makoto Kamiya, Izumi Nishino, Helene D Sabia, Hiromi Endo

Open access · hybridAbstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Biopharmaceutics & drug disposition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Targeting the Arginine Vasopressin VNeuropsychiatric disease and treatment · 2023
    Review
  5. Epigenetic Modulation of Vasopressin Expression in Health and Disease.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shoko InataniDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.ORCID https://orcid.org/0000-0001-7957-715X
Akiko Mizuno-YasuhiraDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Makoto KamiyaDevelopment Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Izumi NishinoDevelopment Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Helene D SabiaClinical Operations, Taisho Pharmaceutical R&D Inc., NJ, USA.
Hiromi EndoDrug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Taisho Pharmaceutical (Japan) · JPTaisho Pharmaceutical (Japan) · JP

Funding

Taisho Pharmaceutical Co., Ltd.; Taisho Pharmaceutical R&D Inc.
6 · The paper itself

Abstract

THY1773 is a novel arginine vasopressin 1B (V

Indexed as

Models, BiologicalAdultAnimalsAntidiuretic Hormone Receptor AntagonistsBlood ProteinsCell Membrane PermeabilityCytochrome P-450 Enzyme SystemDogsDouble-Blind MethodFastingFemaleHumansMaleMicrosomes, LiverMiddle AgedPhenotypeAntidiuretic Hormone Receptor AntagonistsBlood ProteinsCytochrome P-450 Enzyme SystemReceptors, Vasopressineffective dose predictionreceptor occupancyTHY1773TS-121V1B receptor

Identifiers

PMID33734452
PMCPMC8252455
OpenAlexW3139460534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.