ArticleJournal of the National Cancer Institute2021
Long-Term Colorectal Cancer Incidence and Mortality After Colonoscopy Screening According to Individuals' Risk Profiles.
Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acceptability and perceptions of personalised risk-based cancer screening among health-care professionals and the general public: a systematic review and meta-analysis.The Lancet. Public health · 2025Pooled it
- The role of depression in adherence to colorectal cancer screening guidelines.The mental health clinician · 2026Article
- Socioeconomic disparities in survival of patients with superficial colorectal cancer.Discover oncology · 2026Article
- Bayesian model prediction of colorectal cancer incidence in Jiangsu Province, China, a cancer registry-based study.BMC public health · 2026Article
- Stool and blood biomarkers for colorectal cancer management: an update on screening and disease monitoring.Molecular cancer · 2024Review
- Development and validation of machine learning models for young-onset colorectal cancer risk stratification.NPJ precision oncology · 2024Article
- Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data.Cancer biology & medicine · 2024Article
- External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study.International journal of colorectal disease · 2024Article
- Article
- Colorectal Cancer Risk Assessment and Precision Approaches to Screening: Brave New World or Worlds Apart?Gastroenterology · 2023Review
- Colonoscopic Screening and Risk of All-Cause and Colorectal Cancer Mortality in Young and Older Individuals.Cancer research and treatment · 2023Article
- Early-life exposures and adulthood cancer risk: A life course perspective.Journal of the National Cancer Institute · 2023Article
- Implementation of an organized colorectal cancer screening program through quantitative fecal immunochemical test followed by colonoscopy in an urban low-income community: Guidance and strategies.Clinics (Sao Paulo, Brazil) · 2023Article
- Endoscopic Screening and Risk of Colorectal Cancer according to Type 2 Diabetes Status.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- FIT-based risk-stratification model effectively screens colorectal neoplasia and early-onset colorectal cancer in Chinese population: a nationwide multicenter prospective study.Journal of hematology & oncology · 2022Article
- Tobacco Smoking and Gastrointestinal Cancer Risk.Visceral medicine · 2022Review
- Changes in Lifestyle Factors After Endoscopic Screening: A Prospective Study in the United States.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- RE: Long-Term Colorectal Cancer Incidence and Mortality After Colonoscopy Screening According to Individuals' Risk Profiles.Journal of the National Cancer Institute · 2022Article
- Realizing the Promise of Personalized Colorectal Cancer Screening in Practice.Journal of the National Cancer Institute · 2021Article
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Abstract
backgroundIt remains unknown whether the benefit of colonoscopy screening against colorectal cancer (CRC) and the optimal age to start screening differ by CRC risk profile.
methodsAmong 75 873 women and 42 875 men, we defined a CRC risk score (0-8) based on family history, aspirin, height, body mass index, smoking, physical activity, alcohol, and diet. We calculated colonoscopy screening-associated hazard ratios and absolute risk reductions (ARRs) for CRC incidence and mortality and age-specific CRC cumulative incidence according to risk score. All statistical tests were 2-sided.
resultsDuring a median of 26 years of follow-up, we documented 2407 CRC cases and 874 CRC deaths. Although the screening-associated hazard ratio did not vary by risk score, the ARRs in multivariable-adjusted 10-year CRC incidence more than doubled for individuals with scores 6-8 (ARR = 0.34%, 95% confidence interval [CI] = 0.26% to 0.42%) compared with 0-2 (ARR = 0.15%, 95% CI = 0.12% to 0.18%, Ptrend < .001). Similar results were found for CRC mortality (ARR = 0.22%, 95% CI = 0.21% to 0.24% vs 0.08%, 95% CI = 0.07% to 0.08%, Ptrend < .001). The ARR in mortality of distal colon and rectal cancers was fourfold higher for scores 6-8 than 0-2 (distal colon cancer: ARR = 0.08%, 95% CI = 0.07% to 0.08% vs 0.02%, 95% CI = 0.02% to 0.02%, Ptrend < .001; rectal cancer: ARR = 0.08%, 95% CI = 0.08% to 0.09% vs 0.02%, 95% CI = 0.02% to 0.03%, Ptrend < .001). When using age 45 years as the benchmark to start screening, individuals with risk scores of 0-2, 3, 4, 5, and 6-8 attained the threshold CRC risk level (10-year cumulative risk of 0.47%) at age 51 years, 48 years, 45 years, 42 years, and 38 years, respectively.
conclusionsThe absolute benefit of colonoscopy screening is more than twice higher for individuals with the highest than lowest CRC risk profile. Individuals with a high- and low-risk profile may start screening up to 6-7 years earlier and later, respectively, than the recommended age of 45 years.
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