Evidence map›Paper›PMID 33734357›Full record

ArticleG3 (Bethesda, Md.)2021

MultiPhATE2: code for functional annotation and comparison of phage genomes.

Carol L Ecale Zhou, Jeffrey Kimbrel, Robert Edwards, Katelyn McNair, Brian A Souza, Stephanie Malfatti

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Knowing and Naming: Phage Annotation and Nomenclature for Phage Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Pharokka: a fast scalable bacteriophage annotation tool.Bioinformatics (Oxford, England) · 2023
    Article
  15. Article
  16. Computational Tools for the Analysis of Uncultivated Phage Genomes.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carol L Ecale ZhouGlobal Security Computing Applications, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Jeffrey KimbrelBiosciences & Biotechnology Research Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.ORCID 0000-0001-7213-9392
Robert EdwardsComputational Sciences Research Center, San Diego State University, San Diego, CA 92182, USA.
Katelyn McNairComputational Sciences Research Center, San Diego State University, San Diego, CA 92182, USA.
Brian A SouzaBiosciences & Biotechnology Research Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Stephanie MalfattiBiosciences & Biotechnology Research Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

Funding

Computational and Experimental Resources for Virome Analysis in Inflammatory Bowel Disease (CERVAID)RC2DK116713 · NIDDK · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2019 to 2023
$8.9M
NIDDK NIH HHS RC2 DK116713
6 · The paper itself

Abstract

To address a need for improved tools for annotation and comparative genomics of bacteriophage genomes, we developed multiPhATE2. As an extension of multiPhATE, a functional annotation code released previously, multiPhATE2 performs gene finding using multiple algorithms, compares the results of the algorithms, performs functional annotation of coding sequences, and incorporates additional search algorithms and databases to extend the search space of the original code. MultiPhATE2 performs gene matching among sets of closely related bacteriophage genomes, and uses multiprocessing to speed computations. MultiPhATE2 can be re-started at multiple points within the workflow to allow the user to examine intermediate results and adjust the subsequent computations accordingly. In addition, multiPhATE2 accommodates custom gene calls and sequence databases, again adding flexibility. MultiPhATE2 was implemented in Python 3.7 and runs as a command-line code under Linux or MAC operating systems. Full documentation is provided as a README file and a Wiki website.

Indexed as

BacteriophagesAlgorithmsGenomeGenomicsMolecular Sequence AnnotationSoftwarebacteriophagebioinformatics toolcomparative genomicsgene predictiongenome annotationphage

Identifiers

PMID33734357
PMCPMC8104953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.