Evidence map›Paper›PMID 33734097›Full record

ArticleJournal of breath research2021

Using the US EPA CompTox Chemicals Dashboard to interpret targeted and non-targeted GC-MS analyses from human breath and other biological media.

Joachim D Pleil, Charles N Lowe, M Ariel Geer Wallace, Antony J Williams

Abstract read
In one paragraph

Article in Journal of breath research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joachim D PleilGillings School of Public Health, University of North Carolina, Chapel Hill, NC, United States of America.ORCID 0000-0001-8211-0796
Charles N LoweCenter for Computational Toxicology and Exposure, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States of America.ORCID 0000-0001-9151-6157
M Ariel Geer WallaceCenter for Environmental Measurement and Modeling, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States of America.ORCID 0000-0002-3966-5101
Antony J WilliamsCenter for Computational Toxicology and Exposure, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States of America.ORCID 0000-0002-2668-4821

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

The U.S. EPA CompTox Chemicals Dashboard is a freely available web-based application providing access to chemistry, toxicity, and exposure data for ∼900 000 chemicals. Data, search functionality, and prediction models within the Dashboard can help identify chemicals found in environmental analyses and human biomonitoring. It was designed to deliver data generated to support computational toxicology to reduce chemical testing on animals and provide access to new approach methodologies including prediction models. The inclusion of mass and formula-based searches, together with relevant ranking approaches, allows for the identification and prioritization of exogenous (environmental) chemicals from high resolution mass spectrometry in need of further evaluation. The Dashboard includes chemicals that can be detected by liquid chromatography, gas chromatography-mass spectrometry (GC-MS) and direct-MS analyses, and chemical lists have been added that highlight breath-borne volatile and semi-volatile organic compounds. The Dashboard can be searched using various chemical identifiers (e.g. chemical synonyms, CASRN and InChIKeys), chemical formula, MS-ready formulae monoisotopic mass, consumer product categories and assays/genes associated with high-throughput screening data. An integrated search at a chemical level performs searches against PubMed to identify relevant published literature. This article describes specific procedures using the Dashboard as a first-stop tool for exploring both targeted and non-targeted results from GC-MS analyses of chemicals found in breath, exhaled breath condensate, and associated aerosols.

Indexed as

Breath TestsAnimalsChromatography, LiquidGas Chromatography-Mass SpectrometryHumansUnited StatesUnited States Environmental Protection AgencyVolatile Organic CompoundsVolatile Organic Compounds

Identifiers

PMID33734097
PMCPMC12883259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.