Evidence map›Paper›PMID 33734096›Full record

ArticleJournal of medical Internet research2021

Predicting Outcomes in Patients Undergoing Pancreatectomy Using Wearable Technology and Machine Learning: Prospective Cohort Study.

Heidy Cos, Dingwen Li, Gregory Williams, Jeffrey Chininis, Ruixuan Dai, Jingwen Zhang, Rohit Srivastava, Lacey Raper, Dominic Sanford, William Hawkins and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Heidy Cos *Washington University in St Louis, St Louis, MO, United States.ORCID 0000-0001-7721-0848
Dingwen Li *Washington University in St Louis, St Louis, MO, United States.ORCID 0000-0002-9231-7317
Gregory WilliamsWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0003-3196-2766
Jeffrey ChininisWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0001-8545-1182
Ruixuan DaiWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0003-2151-4177
Jingwen ZhangWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0002-8092-1488
Rohit SrivastavaWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0003-2184-5363
Lacey RaperWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0001-8948-6374
Dominic SanfordWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0001-9487-1621
William HawkinsWashington University in St Louis, St Louis, MO, United States.ORCID 0000-0001-7087-3585
Chenyang Lu *Washington University in St Louis, St Louis, MO, United States.ORCID 0000-0003-1709-6769
Chet W Hammill *Washington University in St Louis, St Louis, MO, United States.ORCID 0000-0001-9749-0824
Washington University in St. Louis · USBarnes-Jewish Hospital · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University SPORE in Pancreatic CancerP50CA196510 · NCI · WASHINGTON UNIVERSITY · PI HAWKINS, WILLIAM G · 2016 to 2020
$10.9M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA196510
6 · The paper itself

Abstract

backgroundPancreatic cancer is the third leading cause of cancer-related deaths, and although pancreatectomy is currently the only curative treatment, it is associated with significant morbidity.

objectiveThe objective of this study was to evaluate the utility of wearable telemonitoring technologies to predict treatment outcomes using patient activity metrics and machine learning.

methodsIn this prospective, single-center, single-cohort study, patients scheduled for pancreatectomy were provided with a wearable telemonitoring device to be worn prior to surgery. Patient clinical data were collected and all patients were evaluated using the American College of Surgeons National Surgical Quality Improvement Program surgical risk calculator (ACS-NSQIP SRC). Machine learning models were developed to predict whether patients would have a textbook outcome and compared with the ACS-NSQIP SRC using area under the receiver operating characteristic (AUROC) curves.

resultsBetween February 2019 and February 2020, 48 patients completed the study. Patient activity metrics were collected over an average of 27.8 days before surgery. Patients took an average of 4162.1 (SD 4052.6) steps per day and had an average heart rate of 75.6 (SD 14.8) beats per minute. Twenty-eight (58%) patients had a textbook outcome after pancreatectomy. The group of 20 (42%) patients who did not have a textbook outcome included 14 patients with severe complications and 11 patients requiring readmission. The ACS-NSQIP SRC had an AUROC curve of 0.6333 to predict failure to achieve a textbook outcome, while our model combining patient clinical characteristics and patient activity data achieved the highest performance with an AUROC curve of 0.7875.

conclusionsMachine learning models outperformed ACS-NSQIP SRC estimates in predicting textbook outcomes after pancreatectomy. The highest performance was observed when machine learning models incorporated patient clinical characteristics and activity metrics.

Indexed as

PancreatectomyWearable Electronic DevicesCohort StudiesHumansMachine LearningPostoperative ComplicationsProspective StudiesRetrospective StudiesRisk Assessmentactivitymachine learningpancreatectomypancreatic cancerremote monitoringtelemonitoringwearable technology

Identifiers

PMID33734096
PMCPMC8074869
OpenAlexW3136031576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.