Evidence map›Paper›PMID 33734020›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Morroniside protects OLN-93 cells against H

Fengzhi Li, Xue Song, Jiaxin Xu, Yujiao Shi, Ruina Hu, Zhen Ren, Qi Qi, Hezuo Lü, Xiaoxin Cheng, Jianguo Hu

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fengzhi LiDepartment of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Xue SongDepartment of Central Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.
Jiaxin XuDepartment of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Yujiao ShiDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.
Ruina HuDepartment of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Zhen RenDepartment of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Qi QiAnhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Hezuo LüDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.
Xiaoxin ChengDepartment of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Jianguo HuDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.ORCID 0000-0002-9055-874X
Dalian Medical University · CNBengbu Medical College · CNFirst Affiliated Hospital of Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disorders, including spinal cord injury (SCI), result in oxidative stress-induced cell damage. Morroniside (MR), a major active ingredient of the Chinese herb Shan Zhu Yu, has been shown to ameliorate oxidative stress and inflammatory response. Our previous study also confirmed that morroniside protects SK-N-SH cell line (human neuroblastoma cells) against oxidative impairment. However, it remains unclear whether MR also plays a protective role for oligodendrocytes that are damaged following SCI. The present study investigated the protective effects of MR against hydrogen peroxide (H

Indexed as

AnimalsApoptosisCell LineCell SurvivalCytoprotectionDose-Response Relationship, DrugGlycosidesHydrogen PeroxideOligodendrogliaOxidative StressPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSignal TransductionGlycosidesHydrogen PeroxidemorronisidePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktantiapoptotic activitiesantioxidative stressH2O2MorronisideOLN-93 cellsPI3K/Akt

Identifiers

PMID33734020
PMCPMC8078696
OpenAlexW3136922620

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.