Evidence map›Paper›PMID 33734005›Full record

ArticleLeukemia & lymphoma2021

Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell lymphocytosis, and small lymphocytic lymphoma.

Jayalakshmi Balakrishna, Neil Basumallik, Robert Matulonis, Drake Scott, Dalia Salem, Gregory Jasper, Adrian Wiestner, Maryalice Stetler-Stevenson, Gerald Marti, Clare Sun and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Clinical Flow Cytometric Testing in Chronic Lymphocytic Leukemia.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Jayalakshmi BalakrishnaLaboratory of Pathology, Department of Flow Cytometry, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.ORCID 0000-0002-8906-2704
Neil BasumallikHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
Robert MatulonisWalter Reed National Military Medical Center, Bethesda, MD, USA.
Drake ScottLaboratory of Pathology, Department of Flow Cytometry, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.
Dalia SalemLaboratory of Pathology, Department of Flow Cytometry, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.ORCID 0000-0002-4209-2260
Gregory JasperLaboratory of Pathology, Department of Flow Cytometry, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.
Adrian WiestnerHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
Maryalice Stetler-StevensonLaboratory of Pathology, Department of Flow Cytometry, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.
Gerald MartiHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
Clare SunHematology Branch, NHLBI, NIH, Bethesda, MD, USA.ORCID 0000-0001-8498-4729
Constance M YuanLaboratory of Pathology, Department of Flow Cytometry, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.ORCID 0000-0002-2601-3665
Center for Cancer Research · USNational Institutes of Health · USMansoura University · EGThe Ohio State University Wexner Medical Center · USWalter Reed National Military Medical Center · US

Funding

Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapyZIAHL002346 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WIESTNER, ADRIAN U · 2009 to 2025
$29.8M
Immunotherapy of low grade lymphoid malignanciesZIAHL006070 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WIESTNER, ADRIAN U · 2010 to 2025
$15.9M
Flow Cytometric Evaluation of BiomarkersZICBC011104 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, HAO-WEI · 2009 to 2025
$8.6M
Intramural NIH HHS ZIA HL006070
6 · The paper itself

Abstract

We demonstrate the prognostic utility of antigen quantitation in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis (MBL). Median antibody-bound-per-cell (ABC) of CD20, CD22, CD25, CD19, and %CD38(+) was determined in CLL (185/208), SLL (8/208) and MBL (15/208) cases by flow cytometry, then compared to Dohner-classification, immunoglobulin status (mutated, IGHV-M; unmutated, IGHV-U), CLL-IPI risk and time to first treatment (TTFT). Trisomy 12 cases showed increased %CD38-expression (

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellLymphocytosisB-LymphocytesHumansImmunoglobulin Heavy ChainsMutationPrognosisImmunoglobulin Heavy Chainsantibody binding capacityantigen quantitationchronic lymphocytic leukemiaFlow cytometrymean fluorescence intensityprognosis

Identifiers

PMID33734005
PMCPMC9464423
OpenAlexW3138600044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.