Evidence map›Paper›PMID 33733999›Full record

ArticleRNA biology2021

crRNA complementarity shifts endogenous CRISPR-Cas systems between transcriptional repression and DNA defense.

Hannah K Ratner, David S Weiss

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hannah K RatnerMicrobiology and Molecular Genetics Program, Emory University, Atlanta, GA, USA.
David S WeissEmory Vaccine Center, Emory University, Atlanta, GA, USA.
Emory University · US

Funding

CRISPR/Cas systems in bacterial gene regulation and virulenceR01AI110701 · NIAID · EMORY UNIVERSITY · PI WEISS, DAVID S · 2014 to 2018
$2.2M
NIAID NIH HHS R01 AI110701
6 · The paper itself

Abstract

CRISPR-Cas systems are prokaryotic adaptive immune systems that recognize and cleave nucleic acid targets using small RNAs called CRISPR RNAs (crRNAs) to guide Cas protein(s). There is increasing evidence for the broader endogenous roles of these systems. The CRISPR-Cas9 system of

Indexed as

CRISPR-Cas SystemsTranscription, GeneticVirulenceBacterial ProteinsDNA, BacterialFrancisellaRNA, BacterialBacterial ProteinsDNA, BacterialRNA, BacterialautoimmunityCas12aCas9Cpf1CRISPR-CasDNA targetingfrancisellaself-targetingtranscriptional regulation

Identifiers

PMID33733999
PMCPMC8583161
OpenAlexW3136667919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.