Evidence map›Paper›PMID 33733818›Full record

ArticleJournal of the American Heart Association2021

Mucosal-Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation.

Sho Nakajima, Ryota Tanaka, Kazuo Yamashiro, Asako Chiba, Daisuke Noto, Toshiki Inaba, Naohide Kurita, Nobukazu Miyamoto, Takuma Kuroki, Hideki Shimura and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The immune system in neurological diseases: What innate-like T cells have to say.The Journal of allergy and clinical immunology · 2024
    Review
  5. The MR1/MAIT cell axis in CNS diseases.Brain, behavior, and immunity · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Innate immunity and early liver inflammation.Frontiers in immunology · 2023
    Review
  10. Review
  11. MAITabolismFrontiers in immunology · 2022
    Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sho NakajimaDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Ryota TanakaDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Kazuo YamashiroDepartment of Neurology Juntendo University Urayasu Hospital Chiba Japan.
Asako ChibaDepartment of Immunology Juntendo University Faculty of Medicine Tokyo Japan.
Daisuke NotoDepartment of Immunology Juntendo University Faculty of Medicine Tokyo Japan.
Toshiki InabaDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Naohide KuritaDepartment of Neurology Juntendo University Urayasu Hospital Chiba Japan.
Nobukazu MiyamotoDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Takuma KurokiDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Hideki ShimuraDepartment of Neurology Juntendo University Urayasu Hospital Chiba Japan.
Yuji UenoDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Takao UrabeDepartment of Neurology Juntendo University Urayasu Hospital Chiba Japan.
Sachiko MiyakeDepartment of Immunology Juntendo University Faculty of Medicine Tokyo Japan.
Nobutaka HattoriDepartment of Neurology Juntendo University Faculty of Medicine Tokyo Japan.
Juntendo University · JPJuntendo University Urayasu Hospital · JPJichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Mucosal-associated invariant T (MAIT) cells have been associated with inflammation in several autoimmune diseases. However, their relation to ischemic stroke remains unclear. This study attempted to elucidate the role of MAIT cells in acute ischemic stroke in mice. Methods and Results We used MR1 knockout C57BL/6 (MR1

Indexed as

Immunity, CellularAcute DiseaseAnimalsDisease Models, AnimalInflammationIschemic StrokeMiceMice, Inbred C57BLMice, KnockoutMucosal-Associated Invariant T Cellscerebral infarctionmajor histocompatibility complex‐related protein 1mucosal‐associated invariant T cellsneuroinflammationneuroprotection

Identifiers

PMID33733818
PMCPMC8174378
OpenAlexW3139524672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.