Evidence map›Paper›PMID 33733673›Full record

ArticleEuropean heart journal2021

Road traffic noise and cardiovascular disease risk factors in UK Biobank.

Zuzana Kupcikova, Daniela Fecht, Rema Ramakrishnan, Charlotte Clark, Yutong Samuel Cai

Open access · hybridAbstract read
In one paragraph

Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
25.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  4. Quantifying the Health Benefits Linked to Reduced Traffic-Related PMEnvironment & health (Washington, D.C.) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zuzana KupcikovaAcoustics, Ove Arup & Partners, 13 Fitzroy Street, London W1T 4BQ, UK.ORCID 0000-0003-1008-8379
Daniela FechtMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.ORCID 0000-0002-0738-0013
Rema RamakrishnanNuffield Department of Women's & Reproductive Health, Women's Centre (Level 3), John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-6784-8319
Charlotte ClarkAcoustics, Ove Arup & Partners, 13 Fitzroy Street, London W1T 4BQ, UK.ORCID 0000-0003-3031-4986
Yutong Samuel CaiMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.ORCID 0000-0003-1601-2199
Arup Group (United Kingdom) · GBJohn Radcliffe Hospital · GBImperial College London · GB

Funding

British Heart Foundation CH/1996001/9454Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/M501669/1Medical Research Council MR/S019669/1
6 · The paper itself

Abstract

aimsThe aim of this study was to investigate the cross-sectional associations of modelled residential road traffic noise with cardiovascular disease risk factors [systolic (SBP) and diastolic blood pressure (DBP), C-reactive protein, triglycerides, glycated haemoglobin, and self-reported hypertension] in UK Biobank. METHODS AND

resultsThe UK Biobank recruited 502 651 individuals aged 40-69 years across the UK during 2006-10. Road traffic noise (Lden and Lnight) exposure for 2009 was estimated at baseline address using a simplified version of the Common Noise Assessment Methods model. We used multivariable linear and logistic regression models, adjusting for age, sex, body mass index (BMI), smoking, alcohol intake, area- and individual-level deprivation, season of blood draw, length of time at residence, and nitrogen dioxide (main model), in an analytical sample size of over 370 000 participants. Exposure to road-traffic Lden >65 dB[A], as compared to ≤55 dB[A], was associated with 0.77% [95% confidence interval (CI) 0.60%, 0.95%], 0.49% (95% CI 0.32%, 0.65%), 0.79% (95% CI 0.11%, 1.47%), and 0.12% (95% CI -0.04%, 0.28%) higher SBP, DBP, triglycerides, and glycated haemoglobin, respectively. Removing BMI from the main model yielded significant positive associations with all five markers with elevated percent changes. The associations with SBP or DBP did not appear to be impacted by hypertension medication while a positive association with prevalent self-reported hypertension was seen in the non-medicated group who exposed to a Lden level of 60-65 dB[A] (odds ratio 1.07, 95% CI 1.00, 1.15).

conclusionExposure to road traffic noise >65 dB[A], independent of nitrogen dioxide, was associated with small but adverse changes in blood pressure and cardiovascular biochemistry.

Indexed as

Cardiovascular DiseasesNoise, TransportationBiological Specimen BanksCross-Sectional StudiesEnvironmental ExposureHumansRisk FactorsUnited KingdomAir pollutionBlood glucoseBlood lipidsBlood pressureInflammationTransportation

Identifiers

PMID33733673
PMCPMC8169156
OpenAlexW3132097508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.