ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Brain Small-Worldness Properties and Perceived Fatigue in Mild Cognitive Impairment.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Impact of action observation therapy on motor and cognitive outcomes in older adults with mild cognitive impairment: a randomized controlled study.Frontiers in public health · 2025Trial
- High-Definition Brain Network (HDBN) Delineation of CDKL5 Deficiency Disorder (CDD) in Genetically Engineered Mice.Biomolecules · 2026Article
- Article
- Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross-Etiologic Study.Human brain mapping · 2025Article
- Vision-based estimation of fatigue and engagement in cognitive training sessions.Artificial intelligence in medicine · 2024Article
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade.Aging clinical and experimental research · 2024Review
- Risk-Taking Behavior Differs Between Older Adults with and without Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Combining motion performance with EEG for diagnosis of mild cognitive impairment: a new perspective.Frontiers in neuroscience · 2024Article
- EEG and ERP biosignatures of mild cognitive impairment for longitudinal monitoring of early cognitive decline in Alzheimer's disease.PloS one · 2024Article
- Sex differences in human brain networks in normal and psychiatric populations from the perspective of small-world properties.Frontiers in psychiatry · 2024Review
- Fatigue in Alzheimer's disease: biological basis and clinical management-a narrative review.Aging clinical and experimental research · 2023Review
- Review
- A Multi-Dimensional Model of Fatigue in Old Age: Implications for Brain Aging.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Unifying framework for cognitive training interventions in brain aging.Ageing research reviews · 2022Review
- Altered functional connectivity and topology structures in default mode network induced by inflammatory exposure in aged rat: A resting-state functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2022Article
- A Methodological Framework to Capture Neuromuscular Fatigue Mechanisms Under Stress.Frontiers in neuroergonomics · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPerceived fatigue is among the most common complaints in older adults and is substantially influenced by diminished resources or impaired structure of widespread cortical and subcortical regions. Alzheimer's disease and its preclinical stage-mild cognitive impairment (MCI)-are considered a brain network disease. It is unknown, however, whether those with MCI will therefore perceive worse fatigue, and whether an impaired global brain network will worsen their experience of fatigue.
methodsIn this pilot case-control study of age-, sex-, and education-matched MCI and their cognitively healthy counterparts (HCs), perceived fatigue was measured using Multidimensional Fatigue Inventory, and diffusion tensor imaging tractography data were analyzed using graph theory methods to explore small-worldness properties: segregation and integration.
resultsPerceived fatigue was more severe in MCI than HCs. Despite a trend for greater network alterations in MCI, there were no significant group differences in integration or segregation. Greater perceived fatigue was related to higher segregation across groups; more perceived fatigue was related to higher segregation and lower integration in MCI but not HCs.
conclusionFindings of this study support the notion that altered whole-brain small-worldness properties in brain aging or neurodegeneration may underpin perceived fatigue.
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Registered trials
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