Evidence map›Paper›PMID 33733659›Full record

ReviewFEMS microbiology reviews2021

Host restriction, pathogenesis and chronic carriage of typhoidal Salmonella.

Amber J Barton, Jennifer Hill, Christoph J Blohmke, Andrew J Pollard

Open access · hybridAbstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Protein-centric mechanisms of typhoidalFrontiers in cellular and infection microbiology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amber J BartonOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, UK.ORCID 0000-0001-8313-8643
Jennifer HillOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, UK.
Christoph J BlohmkeOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, UK.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, UK.
National Institute for Health Research · GBUniversity of London · GB

Funding

NIHR 10.13039/501100013373
6 · The paper itself

Abstract

While conjugate vaccines against typhoid fever have recently been recommended by the World Health Organization for deployment, the lack of a vaccine against paratyphoid, multidrug resistance and chronic carriage all present challenges for the elimination of enteric fever. In the past decade, the development of in vitro and human challenge models has resulted in major advances in our understanding of enteric fever pathogenesis. In this review, we summarise these advances, outlining mechanisms of host restriction, intestinal invasion, interactions with innate immunity and chronic carriage, and discuss how this knowledge may progress future vaccines and antimicrobials.

Indexed as

Typhoid FeverTyphoid-Paratyphoid VaccinesHumansSalmonellaSalmonella paratyphi ASalmonella typhiTyphoid-Paratyphoid Vaccinesbacterial pathogenesisenteric feverenteric infectionSalmonella Paratyphi ASalmonella Typhityphoid

Identifiers

PMID33733659
PMCPMC8498562
OpenAlexW3135708134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.