ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2021
Long-term outcome of targeted therapy for low back pain in elderly degenerative lumbar scoliosis.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Spatiotemporal immunomodulation with programmable biomaterials to promote musculoskeletal tissue regeneration.Bioactive materials · 2026Review
- Cement discoplasty for degenerative low back pain: a delphi consensus survey of expert opinion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Clinical effectiveness of lumbosacral orthoses in chronic non-specific low back pain: a systematic review.Frontiers in rehabilitation sciences · 2026Review
- Efficacy of percutaneous cement discoplasty combined with PVP for the treatment of stage III Kümmell disease with an adjacent disc vacuum sign.Frontiers in surgery · 2025Article
- Motion attenuation surgery in the degenerative lumbar spine: Is cement discoplasty a safe and effective option?Brain & spine · 2025Article
- Biomechanical evaluation of percutaneous cement discoplasty combined with percutaneous vertebroplasty: a finite element analysis.Frontiers in bioengineering and biotechnology · 2025Article
- Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.BMC musculoskeletal disorders · 2024Article
- Short-segment spinal fusion for chronic low back pain with bone marrow edema adjacent to the vertebral endplate in adult spinal deformity.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Percutaneous endoscopic lumbar discectomy for single and double segment lumbar disc herniation with sciatic scoliosis in adults: a retrospective study.BMC surgery · 2024Article
- Treatment of degenerative lumbar scoliosis using transforaminal lumbar interbody fusion based on the concept of intervertebral correction.International orthopaedics · 2023Article
- Biomechanical evaluation of percutaneous cement discoplasty by finite element analysis.BMC musculoskeletal disorders · 2022Article
- Letter to the Editor concerning "Long-term outcome of targeted therapy for low back pain in elderly degenerative lumbar scoliosis" by Yamada K, et al. (Eur Spine J. 2021;30(7):2020-2032).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Answer to the Letter to the Editor of G. Camino-Willhuber concerning "Long-term outcome of targeted therapy for low back pain in elderly degenerative lumbar scoliosis" by Yamada K, et al. (Eur Spine J. 2021;30(7):2020-2032).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Low-Modulus PMMA Has the Potential to Reduce Stresses on Endplates after Cement Discoplasty.Journal of functional biomaterials · 2022Article
- AnFrontiers in bioengineering and biotechnology · 2022Article
- Reply to A. Lazary's Expert's Comment concerning grand rounds case entitled "Percutaneous cement discoplasty for the treatment of advanced degenerative disk disease in elderly patients" (C. Sola, et al., Eur Spine J; 2021;30(8):2209-2210. doi:10.1007/s00586-020-06568-4).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Critical Review of the State-of-the-Art on Lumbar Percutaneous Cement Discoplasty.Frontiers in surgery · 2022Review
- Accuracy of intraoperative neuromonitoring during percutaneous cement discoplasty.Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTreatment of low back pain (LBP) associated with elderly degenerative lumbar scoliosis (DLS) remains controversial. We have developed percutaneous intervertebral-vacuum polymethylmethacrylate injection (PIPI) targeting to the intervertebral vacuum as a minimally invasive surgery. The present study compared the long-term clinical outcomes of PIPI to that of nonoperative treatment.
methodsPatients with de novo DLS, aged ≥ 65 years, who had LBP with visual analog scale (VAS) of ≥ 50 for ≥ 6 months with intervertebral vacuum on computed tomography and bone marrow edema (BME) on magnetic resonance imaging were included. The clinical outcomes were evaluated using VAS and the Oswestry Disability Index (ODI) at baseline, 1, 6, 12, 24 months, and at the final follow-up. The course of BME was also evaluated.
resultsOne hundred and one patients underwent PIPI and 61 received nonoperative treatment. The mean follow-up duration after PIPI and nonoperative treatment was 63.7 ± 32.4 and 43.9 ± 20.9 months, respectively. VAS and ODI after PIPI were significantly improved compared to post-nonoperative treatment. BME decreased substantially in the PIPI group and it was significantly correlated with VAS and ODI improvement. Following PIPI, LBP recurred in 28 patients (35%). LBP recurrence was identified at the same level of PIPI in 10 patients, at the adjacent level of PIPI in 11 patients, and at the non-adjacent level of PIPI in seven patients. Eighteen patients underwent additional PIPIs, and both VAS and ODI were significantly improved after additional PIPIs.
conclusionBone marrow lesions of the endplate are strongly associated with the presence of LBP. PIPI can be considered as an effective, safe and repeatable treatment for LBP in elderly DLS patients.
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