Evidence map›Paper›PMID 33733314›Full record

ArticleClinical rheumatology2021

Negative effect of lockdown on juvenile idiopathic arthritis patients.

Giovanni Conti, Francesca Galletta, Nicolina Stefania Carucci, Antonella La Mazza, Salvatore Antonio Mollica, Angela Alibrandi, Carmela Visalli

Abstract read
In one paragraph

Article in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovanni ContiPediatric Nephrology and Rheumatology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", AOU Policlinic G Martino, University of Messina, Via Consolare Valeria, 98124, Messina, Italy. giovaniconti@hotmail.com.ORCID http://orcid.org/0000-0002-0617-500X
Francesca GallettaPediatric Nephrology and Rheumatology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", AOU Policlinic G Martino, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
Nicolina Stefania CarucciPediatric Nephrology and Rheumatology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", AOU Policlinic G Martino, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
Antonella La MazzaPediatric Nephrology and Rheumatology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", AOU Policlinic G Martino, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
Salvatore Antonio MollicaPediatric Nephrology and Rheumatology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", AOU Policlinic G Martino, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
Angela AlibrandiUnit of Statistical and Mathematical Sciences, Department of Economics, University of Messina, Messina, Italy.
Carmela VisalliDivision of Radiology, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study is to evaluate a possible negative action of lockdown, during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, in the follow-up of juvenile idiopathic arthritis (JIA) patients.

methodsWe compared the number of JIA reactivations in the period March-July 2020 to the same months of 2018 and 2019.

resultsA total of 10 JIA reactivations have been documented on 58 patients (17%) visited in the period March-July 2018; 10 reactivations on 61 patients (16%) in the period March-July 2019; and 19 reactivations on 39 patients (49%) in the period March-July 2020, with a statistically significant increase (p <0.001). The other 19 patients who should have been visited during the same period, contacted by phone, indicated remission. Therefore, we hypothesize that the effective number of reactivations in the period March-July 2020 would be 19/58 patients (33%) which remains significantly greater than in the previous 2 years (p < 0.05). Among the 19 JIA patients reactivated in 2020, 3 spontaneously stopped the basic treatment due to parents' choice for fear of serious complications in case of SARS-CoV-2 infection and 4 had poor compliance with underlying treatment. In addition, 14/19 reactivated JIA patients did not perform the scheduled check according to the follow-up. In fact, the mean time interval between two follow-up visits was significantly greater in 2020 (157 ± 53 days, p < 0.0001) vs 2018 (108 ± 68 days) and 2019 (107 ± 40 days).

conclusionsWe have found a significant increase in JIA reactivations in the period March-July 2020 compared to the same interval of 2018 and 2019. This increase may have been caused by poor compliance with background treatment, as documented in 7/19 JIA patients reactivated, and by a greater interval in follow-up checks. Therefore, it is necessary, in occasion of a new pandemic and lockdown, to implement greater controls using more appropriate telemedicine tools. Key Points • COVID-19 pandemic lockdown had a negative effect on the follow-up of JIA patients. • A significant increase in JIA reactivations was found during the lockdown. • Poor therapeutic compliance and follow-up checks have been proven during the lockdown. • It is necessary to improve telemedicine tools and scientific information during a pandemic and lockdown.

Indexed as

Arthritis, JuvenileCOVID-19Communicable Disease ControlHumansPandemicsSARS-CoV-2COVID-19 pandemicJuvenile idiopathic arthritisLockdownSARS-CoV-2Telemedicine tools

Identifiers

PMID33733314
PMCPMC7968921

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.