Trial reportAIDS and behavior2021
Can Individualized-Targeted Computerized Cognitive Training Benefit Adults with HIV-Associated Neurocognitive Disorder? The Training on Purpose Study (TOPS).
Trial report in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults With HIV
Reducing Cognitive Intra-Individual Variability and Cognitive Impairment in Adults With HIV (The Targeted Neurocognitive Training (TNT) Study)
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Evaluation of Computerized Cognitive Training and Cognitive and Daily Function in Patients Living With HIV: A Meta-analysis.JAMA network open · 2022Pooled it
- A 2-Year Longitudinal Randomized Control Trial of Speed of Processing Cognitive Training in Aging Adults with HIV-Associated Neurocognitive Disorder: Results of the Think Fast Study.AIDS and behavior · 2024Trial
- Mindfulness-Based Stress Reduction for Symptom Management in Older Individuals with HIV-Associated Neurocognitive Disorder.AIDS and behavior · 2024Trial
- A 2-year longitudinal randomized controlled trial examining the transfer of speed of processing training to secondary cognitive domains in middle-aged and older adults with HIV-associated neurocognitive disorder: Results of the think fast study.The Clinical neuropsychologist · 2024Trial
- Two-year clinical trial examining the effects of speed of processing training on everyday functioning in adults with human immunodeficiency virus-associated neurocognitive disorder (HAND) and borderline HAND in the U.S. Deep South: Findings of the Think Fast Study.Applied neuropsychology. AdultTrial
- A Randomized Clinical Trial on the Impact of Individually Targeted Computerized Cognitive Training on Quality of Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in the Southeastern United States.The Journal of the Association of Nurses in AIDS Care : JANACTrial
- Cross-sectional observational study evaluating social brain health in HIV using a research domain criteria-based approach: a protocol.BMJ open · 2026Article
- Social cognition abilities in people with HIV: the role of stigma and other factors.AIDS (London, England) · 2025Review
- Cognitive predictors of everyday functioning in women with HIV: findings from the women's interagency HIV study.BMC neurology · 2025Article
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- Advances in assessment and cognitive neurorehabilitation of HIV-related neurocognitive impairment.Brain communications · 2025Review
- A Brief Report of an Executive Functioning Training Pilot RCT in Adults with HIV: A Descriptive Case Comparison Study.Nursing (Auckland, N.Z.) · 2025Article
- Executive Functioning Training for Reducing Cognitive Intra-Individual Variability in People Living with HIV: A Pilot Randomized, Controlled Trial Protocol.Nursing (Auckland, N.Z.) · 2025Article
- Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?Applied neuropsychology. Adult · 2024Article
- Cognitive Intra-Individual Variability as an Outcome or Moderator of Speed of Processing Training in Aging Adults with HIV-Associated Neurocognitive Disorder: A Secondary Data Analysis of a 2-Year Longitudinal Randomized Clinical Trial.Archives of gerontology and geriatrics plus · 2024Article
- Non-pharmaceutical interventions for people living with HIV with cognitive impairment: A scoping review.PloS one · 2024Article
- Pharmacological and Behavioral Interventions to Mitigate Premature Aging in Patients with HIV.Current HIV/AIDS reports · 2023Review
- Social and Neighborhood Context Moderates the Associations Between Processing Speed and Driving Mobility: A 10-year Analysis of the ACTIVE Study.Journal of aging and health · 2023Article
- Computer use: a protective factor for cognition in aging and HIV disease?Aging clinical and experimental research · 2023Article
- Cognitive Intra-individual Variability in HIV: an Integrative Review.Neuropsychology review · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Half of people with HIV (PWH) have HIV-associated neurocognitive disorder (HAND). This study examined whether cognition can be improved using a framework targeting impaired individual cognitive domains in PWH with HAND. In this two-group pre-post experimental design study, 88 adults with HAND were randomized to either: (1) a no-contact control group (n = 40) or (2) the Individualized-Targeted Cognitive Training group (n = 48). Baseline cognitive performance was assessed on eight cognitive domains. A theoretical framework was used to determine the two cognitive domains selected for training. With priority on speed of processing (SOP) and attention impairments, participants received SOP and/or attention training if such impairments were detected; if not, participants were assigned to cognitive training in one/two of the least impaired cognitive domains contributing to their HAND diagnosis. Global cognitive score was slightly improved following training (p = 0.256; d = - 0.21), but it was not significant. Significant improvements were observed on SOP following training in that domain (SOP; d = - 0.88; p = 0.011). SOP training also improved functioning in other cognitive domains. This individualized cognitive intervention did not change HAND status, but it did result in improved SOP, in turn yielding improvement in other cognitive domains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.