Evidence map›Paper›PMID 33733082›Full record

ArticleMetabolism open2021

The presence of 3-hydroxypropionate and 1,3-propanediol suggests an alternative path for conversion of glycerol to Acetyl-CoA.

Eunsook S Jin, Min H Lee, Craig R Malloy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Glycerol waste to value added products and its potential applications.Systems microbiology and biomanufacturing · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eunsook S JinAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Min H LeeAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Craig R MalloyAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn our recent study using [U-

methodsFasted hamsters received acetaminophen (400 mg/kg; n = 16) or saline (n = 10) intraperitoneally. After waiting 2 h, all the animals received [U-

results1,3PDO and 3HP derived from [U-

conclusionDetection of 1,3PDO and 3HP in the hamster liver was associated with unorthodox metabolism of glycerol characterized by conversion of 3HP to acetyl-CoA followed by ketogenesis and oxidative metabolism through the TCA cycle. Additional mechanistic studies are needed to determine the causes of unusual glycerol metabolism in a subset of these hamsters.

Indexed as

1,3PDO, 1,3-propanediol1,3-Propanediol3HP, 3-hydroxypropionate3HPA, 3-hydroxypropionaldehyde3-HydroxypropionateACC, acetyl-CoA carboxylaseAldehyde dehydrogenaseALDH, aldehyde dehydrogenaseDHAP, dihydroxyacetone phosphateG3P, glycerol 3-phosphateGA3P, glyceraldehyde 3-phosphateGAPDH, glyceraldehyde 3-phosphate dehydrogenaseGK, glycerol kinaseGluconeogenesisGlu, glutamateGlyDH, glycerol dehydrogenaseKetogenesisOAA, oxaloacetateOxidative metabolismPCC, propionyl-CoA carboxylasePDH, pyruvate dehydrogenaseα-kG, α-ketoglutarateβ-HB, β-hydroxybutyrate

Identifiers

PMID33733082
PMCPMC7940983
OpenAlexW3134620877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.