Evidence map›Paper›PMID 33733036›Full record

ArticleCurrent developments in nutrition2021

Natural and Synthetic α-Tocopherol Modulate the Neuroinflammatory Response in the Spinal Cord of Adult

Katherine M Ranard, Matthew J Kuchan, Janice M Juraska, John W Erdman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katherine M RanardDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID https://orcid.org/0000-0002-4013-1393
Matthew J KuchanAbbott Nutrition, Columbus, OH, USA.
Janice M JuraskaDepartment of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
John W ErdmanDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
University of Illinois Urbana-Champaign · USAbbott (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin E (α-tocopherol, α-T) deficiency causes neurological pathologies. α-T supplementation improves outcomes, but the relative bioactivities of dietary natural and synthetic α-T in neural tissues are unknown.

objectiveThe aim was to assess the effects of dietary α-T source and dose on oxidative stress and myelination in adult α-tocopherol transfer protein-null (

methodsThree-week-old male

resultsCerebral cortex α-T concentrations were undetectable in

conclusionsNatural and synthetic α-T supplementation normalized neuroinflammatory markers in neural tissues of 10-mo-old

Indexed as

all-rac-α-tocopherolcentral nervous systemoxidative stressRRR-α-tocopherolTtpa-null mousevitamin E

Identifiers

PMID33733036
PMCPMC7947595
OpenAlexW3130735827

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.