Evidence map›Paper›PMID 33732969›Full record

ArticleBioactive materials2021

Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material.

Rui Guo, Feng Wan, Masatoshi Morimatsu, Qing Xu, Tian Feng, Hang Yang, Yichen Gong, Shuhong Ma, Yun Chang, Siyao Zhang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Rui GuoDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Feng WanDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Masatoshi MorimatsuDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Qing XuDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Tian FengDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Hang YangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Yichen GongDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Shuhong MaDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Yun ChangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Siyao ZhangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Youxu JiangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Heqing WangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Dehua ChangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Hongjia ZhangDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Yunpeng LingDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Feng LanDepartment of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, China.
Peking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNOkayama University · JPCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades. However, optimal cell types and transplantation methods remain unclear. This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell (hUCMSC) sheet on myocardial infarction (MI).

methodshUCMSCs expressing luciferase were generated by lentiviral transduction for

resultsWhen transplanted to the infarcted mouse hearts, hUCMSC sheet significantly improved the retention and survival compared with cell suspension. At the early stage of MI, hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages, preserving the cardiomyocytes from acute injury. Moreover, the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue, providing mechanical support and routes for revascularsation. These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.

conclusionshUCMSC sheet formation dramatically improved the biological functions of hUCMSCs, mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart. TRANSLATIONAL PERSPECTIVE: Due to its excellent availability as well as superior local cellular retention and survival, allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs, such as modulating inflammation and enhancing angiogenesis. Moreover, the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial, further improving its clinical applicability.

Indexed as

Cell sheetMesenchymal stem cellsMyocardial infarctionRegulation of inflammatory responseVentricular remodelling

Identifiers

PMID33732969
PMCPMC7941025
OpenAlexW3133770749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.